Results 61 to 70 of about 1,958,325 (325)

SUMO: regulating the regulator

Cell Division, 2006
Post-translational modifiers of the SUMO (Small Ubiquitin-related Modifier) family have emerged as key regulators of protein function and fate. While the past few years have seen an enormous increase in knowledge on SUMO enzymes, substrates, and ...
Bossis Guillaume, Melchior Frauke
doaj   +1 more source

RAP80 interacts with the SUMO-conjugating enzyme UBC9 and is a novel target for sumoylation [PDF]

Biochemical and Biophysical Research Communications, 2007
RAP80, a nuclear protein with two functional ubiquitin-interaction motifs (UIMs) at its N-terminus, plays a critical role in the regulation of estrogen receptor alpha and DNA damage response signaling. A yeast two-hybrid screen identified the SUMO-conjugating enzyme UBC9 as a protein interacting with RAP80.
Xiao Ping Yang, Anton M. Jetten, Jun Yan, Yong-Sik Kim, Joung Hyuck Joo   +4 more
openaire   +3 more sources

The ubiquitin-proteasome pathway in Huntington's disease. [PDF]

, 2008
The accumulation of mutant protein is a common feature of neurodegenerative disease. In Huntington's disease, a polyglutamine expansion in the huntingtin protein triggers neuronal toxicity.
Finkbeiner, Steven, Mitra, Siddhartha
core   +2 more sources

Molecular Characterization and Functional Localization of a Novel SUMOylation Gene in Oryza sativa

Biology, 2021
Small ubiquitin-related modifier (SUMO) regulates the cellular function of diverse proteins through post-translational modifications. The current study defined a new homolog of SUMO genes in the rice genome and named it OsSUMO7. Putative protein analysis
Eid I. Ibrahim, Kotb A. Attia, Abdelhalim I. Ghazy, Kimiko Itoh, Fahad N. Almajhdi, Abdullah A. Al-Doss   +5 more
doaj   +1 more source

SUMO modification of the ubiquitin-conjugating enzyme E2-25K

Nature Structural & Molecular Biology, 2005
Post-translational modification with small ubiquitin-related modifier (SUMO) alters the function of many proteins, but the molecular mechanisms and consequences of this modification are still poorly defined. During a screen for novel SUMO1 targets, we identified the ubiquitin-conjugating enzyme E2-25K (Hip2).
Edith Oberhofer, Puck Knipscheer, Frauke Melchior, Frauke Melchior, Stefan Jentsch, Roman Körner, Titia K. Sixma, Jesper V. Olsen, A. Pichler, A. Pichler, Willem J. van Dijk   +10 more
openaire   +5 more sources

OsSCE1 Encoding SUMO E2-Conjugating Enzyme Involves in Drought Stress Response of Oryza sativa

Rice Science, 2018
Small ubiquitin-like modifier (SUMO)-conjugating enzymes are involved in post-translational regulatory processes in eukaryotes, including the conjugation of SUMO peptides to protein substrate (SUMOylation).
Dini Nurdiani, Dwi Widyajayantie, Satya Nugroho   +2 more
doaj   +1 more source

A role for SUMO modification in transcriptional repression and activation [PDF]

, 2007
Since the discovery of the SUMO (small ubiquitin-like modifier) family of proteins just over a decade ago, a plethora of substrates have been uncovered including many regulators of transcription.
David, Gill, Gomez-del Arco, Gostissa, Hong, I. Stancheva, Ichimura, Kirsh, Klose, Lin, Ling, Lyst, M.J. Lyst, Nathan, Nishida, Rodriguez, Shiio, Shin, Sterner, Uchimura, Verger, Yamaguchi, Yamamoto, Yang, Yang, Yang, Yang   +26 more
core   +1 more source

The maize SUMO conjugating enzyme ZmSCE1b protects plants from paraquat toxicity

Ecotoxicology and Environmental Safety, 2021
Paraquat (PQ) herbicide causes damage to green plant tissues by inducing the production of toxic reactive oxygen species (ROS). SUMOylation is an important post-translational modification that enables plants to defend against multiple stresses. However, it is still unknown whether the SUMOylation is involved in PQ resistance response in crops.
Huanyan Wang, Meiping Wang, Xianfeng Zhu, Dongliang Xu, Zongliang Xia   +4 more
openaire   +4 more sources

Global SUMO proteome responses guide gene regulation, mRNA biogenesis, and plant stress responses

Frontiers in Plant Science, 2012
Small-ubiquitin-like MOdifier (SUMO) is a key regulator of abiotic stress, disease resistance and development in plants. The identification of >350 plant SUMO targets has revealed many processes modulated by SUMO and potential consequences of SUMO on ...
Magdalena eMazur, Harrold Alfred Van Den Burg   +1 more
doaj   +1 more source

Site-specific identification and quantitation of endogenous SUMO modifications under native conditions. [PDF]

, 2017
Small ubiquitin-like modifier (SUMO) modification regulates numerous cellular processes. Unlike ubiquitin, detection of endogenous SUMOylated proteins is limited by the lack of naturally occurring protease sites in the C-terminal tail of SUMO proteins ...
Ahmad, Alla S, Bennett, Eric J, Clauser, Karl R, Gu, Hongbo, Komives, Elizabeth A, Leonard, Marilyn, Lumpkin, Ryan J, Meyer, Jesse G, Zhu, Yiying   +8 more
core   +2 more sources