Results 71 to 80 of about 1,958,325 (325)
Meiosis and small ubiquitin‐related modifier (SUMO)‐conjugating enzyme, Ubc9 [PDF]
The FEBS Journal, 2007 In this review, we describe the role of a small ubiquitin‐like protein modifier (SUMO)‐conjugating protein, Ubc9, in synaptonemal complex formation during meiosis in a basidiomycete, Coprinus cinereus. Because its meiotic cell cycle is long and naturally synchronous, it is suitable for molecular biological, biochemical and genetic studies of meiotic ...
Akiyo Koshiyama +2 more
openaire +2 more sources
Cell Reports, 2014 Chemotherapeutic drugs used in the treatment of acute myeloid leukemias (AMLs) are thought to induce cancer cell death through the generation of DNA double-strand breaks.
Guillaume Bossis +15 more
doaj +1 more source
RBR E3 ubiquitin ligases: new structures, new insights, new questions [PDF]
, 2014 The RBR (RING-BetweenRING-RING) or TRIAD [two RING fingers and a DRIL (double RING finger linked)] E3 ubiquitin ligases comprise a group of 12 complex multidomain enzymes.
Shaw, Gary S. +2 more
core +1 more source
The Role of the Small Ubiquitin-Related Modifier (SUMO) Pathway in Prostate Cancer
Biomolecules, 2012 SUMO (small ubiquitin-related modifier) conjugation is a reversible three-step process of protein post-translational modifications mediating protein-protein interactions, subcellular compartmentalization and regulation of transcriptional events.
Christos N. Papandreou +1 more
doaj +1 more source
Plant Direct, 2020 Small ubiquitin‐like modifier (SUMO) conjugation, or SUMOylation, is a reversible post‐translational modification that is important for regulation of many cellular processes including cell division cycle in the eukaryotic kingdom. However, only a portion
Yen‐Ling Lin +4 more
doaj +1 more source
SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer [PDF]
, 2019 BACKGROUND: Even though liver kinase B1 (LKB1) is usually described as a tumor suppressor in a wide variety of tissues, it has been shown that LKB1 aberrant expression is associated with bad prognosis in Hepatocellular Carcinoma (HCC).
Díaz Moreno, Irene +4 more
core +1 more source
Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal [PDF]
Nature Communications, 2016 AbstractCancer stem cells (CSCs) have key roles in treatment resistance, tumour metastasis and relapse. Using colorectal cancer (CC) cell lines, patient-derived xenograft (PDX) tissues and patient tissues, here we report that CC CSCs, which resist chemoradiation, have higher SUMO activating enzyme (E1) and global SUMOylation levels than non-CSCs ...
Rebecca Wiatrek +8 more
openaire +3 more sources
Sumoylation of Smc5 Promotes Error-free Bypass at Damaged Replication Forks [PDF]
, 2019 Replication of a damaged DNA template can threaten the integrity of the genome, requiring the use of various mechanisms to tolerate DNA lesions. The Smc5/6 complex, together with the Nse2/Mms21 SUMO ligase, plays essential roles in genome stability ...
Apostolova, Sonia +13 more
core +2 more sources
Structural modeling and functional analysis of the essential ribosomal processing protease Prp from Staphylococcus aureus [PDF]
, 2017 In Firmicutes and related bacteria, ribosomal large subunit protein L27 is encoded with a conserved N-terminal extension that is removed to expose residues critical for ribosome function. Bacteria encoding L27 with this N-terminal extension also encode a
Christie, Gail E. +3 more
core +2 more sources
N-terminal α-amino SUMOylation of cofilin-1 is critical for its regulation of actin depolymerization
Nature Communications, 2023 Small ubiquitin-like modifier (SUMO) typically conjugates to target proteins through isopeptide linkage to the ε-amino group of lysine residues. This posttranslational modification (PTM) plays pivotal roles in modulating protein function.
Weiji Weng +10 more
doaj +1 more source