Results 91 to 100 of about 24,946 (242)
Exponential sums over integers without large prime divisors
Monatshefte für MathematikWe obtain a new bound on exponential sums over integers without large prime divisors, improving that of Fouvry and Tenenbaum (1991). For a fixed integer $ν\ne 0$, we also obtain new bounds on exponential sums with $ν$-th powers of such integers. The improvement is based on exploiting more precisely the factorisation of integers without large prime ...
Sary Drappeau, Igor E. Shparlinski
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Summing the largest prime factor over integer sequences
Revista de la Unión Matemática ArgentinaLet \(n=p_1^{\alpha_1}\cdots p_k^{\alpha_k}\). Given fixed integers \(h,r\geq 2\), we say that \(n\) is a \(r\)-free number if \(\max\{\alpha_1,\dots,\alpha_k\}\leq r-1\), and we say that \(n\) is a \(h\)-full number if \(\min\{\alpha_1,\dots,\alpha_k\}\geq h\). In the paper under review, the authors provide asymptotic expansions for the sums \[ \sum_{\
De Koninck, Jean-Marie +1 more
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Sato-Tate distribution of <i>p</i>-adic hypergeometric functions. [PDF]
Res Number Theory, 2023 Pujahari S, Saikia N.
europepmc +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source