Results 191 to 200 of about 24,999 (231)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

open access: yesAging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

open access: yesAging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang   +3 more
wiley   +1 more source

Algorithm-assisted discovery of an intrinsic order among mathematical constants. [PDF]

open access: yesProc Natl Acad Sci U S A
Elimelech R   +8 more
europepmc   +1 more source

Gibbs manifolds. [PDF]

open access: yesInf Geom
Pavlov D, Sturmfels B, Telen S.
europepmc   +1 more source

Character sums over shifted primes

Mathematical Notes, 2010
Let \(q\) be an arbitrary positive integer, \(\chi\) be a primitive character modulo \(q\), and let \(\Lambda(n)\) be the von Mangoldt function. For \(N\leq q^{16/9}\), the authors prove that \[ \left|\sum_{n\leq N}\Lambda(n)\chi(n+a)\right|\leq \left(N^{7/8}q^{1/9}+N^{33/32}q^{-1/18}\right)q^{o(1)}. \]
Friedlander, J. B.   +2 more
openaire   +4 more sources

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