Results 121 to 130 of about 16,504 (199)

Engineering exosomal cargo loading via endogenous molecular pathways: Strategies to enhance therapeutic potential

Interdisciplinary Medicine, EarlyView.
This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu, Chenning Zhang, Shihan Ma, Zhanxue Xu, Cailing Liang, Fang Cheng, Hongbo Chen   +6 more
wiley   +1 more source

Interaction between CDC6 and Tmod3 accelerates resistance to paclitaxel through focal adhesion assembly. [PDF]

Signal Transduct Target Ther
Liu Y, Wang H, Zhan J, Sun J, Sun Y, Fu X, Lv D, Li X, Dong T, Lou H.   +9 more
europepmc   +1 more source

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, EarlyView.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source

In Vivo Imaging of Neuronal Activity Shifts in the Somatosensory Cortex After Morphine Tolerance in Mice. [PDF]

Addict Biol
Zhang G, Meng W, Xu LJ, Mou B, Xiang Z, Ruan X, Liu YU, Shu H.   +7 more
europepmc   +1 more source

Recent Advances (2023–2025) of Capillary Electrophoresis‐Mass Spectrometry (CE‐MS) for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Top‐down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform detection, given the extremely high proteoform complexity and wide proteoform concentration dynamic range.
Guijie Zhu, David A. Alvarez Rodriguez, Noah Gould, Alexander R. Ivanov, Kevin Jooß, Liangliang Sun   +5 more
wiley   +1 more source

Circadian rhythm disruption declines oocyte quality for fertility via PTEN/AKT pathway. [PDF]

Protein Cell
Lu PS, Zhang KH, Wu SL, Ma RJ, Zou YJ, Ju JQ, Zhang HL, Wang Y, Sun SC.   +8 more
europepmc   +1 more source

Generalist‐pollinated Arabis alpina exhibits floral scent variation at multiple scales

Nordic Journal of Botany, EarlyView.
Plants that depend on animals for reproduction often use complex floral traits to attract pollinators. Floral scent is recognized as part of the pollinator attraction module and can be shaped by plant‐pollinator interactions. In recent decades, research has started to reveal the dynamic properties of floral scent, identifying patterns of spatial and ...
Hanna Thosteman, Katherine Eisen, Clara McNaughton Montgomery, Xuefei Cheng, Loretta Pace, Magne Friberg   +5 more
wiley   +1 more source

ERM proteins support perinuclear actin rim formation. [PDF]

Front Cell Dev Biol
Hadad Y, Fracchia A, Babele D, Ben Shushan A, Gerlitz G.   +4 more
europepmc   +1 more source

Rediscovery of Strobilanthes panichanga and discovery of Strobilanthes parryorum (Acanthaceae): two endangered species from the hills of Dima Hasao, Assam, India

Nordic Journal of Botany, EarlyView.
We report on two species of Strobilanthes Blume. Strobilanthes panichanga (Nees) T.Anderson has been rediscovered in the Dima Hasao district of Assam, India, after a very long gap of 150 years, and Strobilanthes parryorum C.E.C.Fisch has been discovered for the first time in Assam, India.
Kapil Kumar Kemprai, Souravjyoti Borah
wiley   +1 more source

Emerging mechanomedicines informed by mechanotransduction along the integrin-cytoskeleton-nucleus axis. [PDF]

APL Bioeng
Yokoyama Y, Domkam N, Kabir H, Mansour A, Tsukamoto S, Yerima G, Adachi T, Mofrad MRK.   +7 more
europepmc   +1 more source