Results 91 to 100 of about 30,680 (264)

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Evidence For Non-Potential Magnetic Fields In The Quiet Sun

, 2007
. A comparison of BBSO Hff centerline filtergrams and videomagnetograms was made to investigate the existence of non-potential magnetic fields in the quiet Sun near magnetic network.
M. F. Woodard, Jongchul Chae
core  

Electron and composite-fermion edge states in nonuniform magnetic fields

, 2001
We investigate the electron transport in two-dimensional electron systems, where spatially nonuniform magnetic fields are applied, using the noninteracting-electron approach and composite-fermion edge state theory.
Ihm, G, Sim, Heung-Sun, Chang, Kee-Joo, Kim, N   +3 more
core   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Protein Disulfide Isomerase Disassembles TDP‐43/G3BP1 Condensates and Antagonizes TDP‐43 Pathological Aggregates

Advanced Science, EarlyView.
Cytoplasmic aggregation of TDP‐43 is a common pathological feature in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer's disease with TDP‐43 pathology. This study reports that wild‐type PDI slows down phase separation of TDP‐43 through direct interaction with TDP‐43.
Jia‐Qi Liu, Hao Liu, Yu‐Xuan Sun, Yuying Li, Xiangyi Liu, Li‐Qiang Wang, Zhaofei Yang, Qi Fu, Xiaojiao Xu, Jie Chen, Yingshuang Zhang, Jun Zhou, Weidong Le, Mengchao Cui, Yi Liang   +14 more
wiley   +1 more source

Inference of magnetic fields in the very quiet Sun

, 2016
Context. Over the past 20 yr, the quietest areas of the solar surface have revealed a weak but extremely dynamic magnetism occurring at small scales (
M. J. Martínez González, Doerr, H. P., Strassmeier, K., Verma, M., J. Staude, Kuckein, Christoph (Dr.), Schmidt, W., Schlichenmaier, R., H. Nicklas, Solanki, S. K., Hofmann, A., Waldman, T., F. Kneer, Balthasar, H., Strassmeier, Klaus G., Sigwarth, M., González Manrique, Sergio Javier, Berkefeld, T., D. Schmidt, Kuckein, C., S. J. González Manrique, T. Waldman, D. Orozco, M. Collados, R. Louis, A. Pastor Yabar, Rezaei, R., A. Asensio Ramos, C. Kuckein, A. Feller, Lagg, A., Louis, R., K. G. Strassmeier, A. Lagg, C. Denker, Volkmer, R., Denker, C., González Manrique, S., Doerr, H., R. Rezaei, Schmidt, D., S. K. Solanki, Pastor Yabar, A., Denker, Carsten (Prof. Dr.), Martinez Gonzalez, M. J., Soltau, D., H. P. Doerr, Franz, M., W. Schmidt, Martínez González, M., Kneer, F., T. Berkefeld, O. von der Lühe, Collados, M., M. Franz, R. Volkmer, Collados Vera, M., Solanki, S., Feller, A., Orozco, D., Nicklas, H., H. Balthasar, M. Verma, Verma, Meetu (Dr.), Staude, J., Asensio Ramos, A., R. Schlichenmaier, Sobotka, M., A. Hofmann, M. Sobotka, D. Soltau, Sobotka, Michal, Balthasar, Horst (Dr.), M. Sigwarth, von der Lühe, O.   +74 more
core   +1 more source

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

On the properties of single-separator MHS equilibria and the nature of separator reconnection

, 2015
This thesis considers the properties of MHS equilibria formed through non-resistive MHD relaxation of analytical non-potential magnetic field models, which contain two null points connected by a generic separator. Four types of analytical magnetic fields
Stevenson, Julie E. H.
core