Results 201 to 210 of about 7,321,305 (293)

Intratumoral Hypoxia Triggers Mitochondrial BHLHE40 ROS Sensing Pathway to Promote Radioresistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Hypoxia triggers a dual mechanism for BHLHE40 upregulation: reactive oxygen species (ROS)‐dependent post‐translational modification and hypoxia‐inducible factor (HIF)‐dependent transcriptional activation. Under hypoxic conditions, mitochondrial BHLHE40 accumulates and senses ROS via cysteine thiol oxidation and disulfide‐linked homodimer formation ...
Jia Liu, Ziliang Nie, Xi Chen, Guangyu Ji, Yajing Zhang, Zhiqun Zhao, Yuhong Zhang, Xinlong Du, Zhenzhen Zhou, Jiayi Li, Yaozong Yang, Fengqi Sun, Zhibo Yan, Haiquan Lu   +13 more
wiley   +1 more source

Increasing topical sunscreen use in German outdoor workers: results of a non-randomised controlled intervention study. [PDF]

BMC Public Health
Dick A, Ludewig M, Skudlik C, Jakasa I, Kezic S, de Boer F, van der Molen H, John SM, Rocholl M.   +8 more
europepmc   +1 more source

Synergistic p53 Pathway Activation Through Sono‐Gene Therapy Induced by Ultrasound‐Triggered Theranostic Mesoporous Nanoparticles

Advanced Science, EarlyView.
Schematic representation of ultrasound‐mediated ICG/siCD24@MSN‐LCD from nanostructure to synergistic sono‐gene therapy. This nanoplatform targets ASGPR via the LCD shell, which dissociates to release loaded ICG and siCD24. The core mechanism involves ultrasound‐guided sonodynamic therapy by ICG and CD24 knockdown by siCD24, both activating the p53 axis
Yading Zhao, Lu Guo, Dandan Shi, Xiao Sun, Mengmeng Shang, Song Ning, Shuting Huang, Xiaoxuan Wang, Rui Liu, Yuye Fu, Suyun Li, Jie Li   +11 more
wiley   +1 more source

Beyond Melanin: A Literature Review of Photoprotection Mechanisms and Gaps in Skin of Color. [PDF]

Cureus
Leybengrub P, Eyob W, Petrossian L, Shetty S, Scott BA, Kebbe MB, Vo K.   +6 more
europepmc   +1 more source

Continuous Evolution System Based on Toxin–Antitoxin System Combined with Base Deaminase Accelerates the In Vivo Modification of Target Proteins

Advanced Science, EarlyView.
The promoted Escherichia coli‐assisted continuous evolution (PEACE) system operates through a stringent three step genetic circuit: target gene mutation via a deaminase–T7 RNA polymerase (T7 RNAP) fusion, coupling variant function to antitoxin expression, and growth based selection of surviving cells.
Xinyu Zhang, Zhanzhi Liu, Ying Xu, Mingjing Sun, Guangzhen Zhou, Deming Rao, Xiaoqian Chen, Sheng Wang, Zhigang Li, Yan Huang, Jing Wu   +10 more
wiley   +1 more source

The Rise in Homemade Sunscreen Trends and Future Impacts on Skin Cancer Risk: Systematic Review. [PDF]

JMIR Dermatol
Kaftan G, Panillo M, Maxon L, Esposito E.   +3 more
europepmc   +1 more source

Nanometer Layer Coating to Lactose Particles for Optimization of Dexamethasone Pulmonary Delivery

Advanced Science, EarlyView.
Nanometer layer coating (NLC) was investigated and its mechanism illustrated by advanced characterization techniques. The effects and application for the inhalation of dexamethasone (DEX) were demonstrated through in vitro and in vivo evaluation. This approach increased DEX bioavailability and enabled the dose to be reduced to 1/30 of the intravenous ...
Qin Nie, Jiahe Liu, Xiangyu Zhao, Siying Yang, Han Sun, Bingqian Jia, Xiaohong Ren, Xintao Chen, Lixin Sun, Li Wu, Caifen Wang, Jiwen Zhang   +11 more
wiley   +1 more source

Childhood ultraviolet exposure and skin cancer prevention: A call for change in national policy in South Africa. [PDF]

J Public Health Afr
Swart M.
europepmc   +1 more source

Drop‐Location‐Insensitive Droplet‐Based Electricity Generator Using Polydimethylsiloxane Slippery Covalently Attached Liquid Coatings

Advanced Science, EarlyView.
Drop‐location sensitivity remains a key barrier to practical droplet‐based electricity generators (DEGs). Here, a polydimethylsiloxane slippery covalently attached liquid (PDMS‐SCAL)‐coated interface promotes droplet sliding instead of splitting or bouncing, allowing stable electricity generation from randomly falling raindrops. The resulting PDMS‐SCAL‐
Jung Bin Yang, Donghyeon Yoo, Hideaki Teshima, Donghan Lee, Dongwhi Choi, Dong Rip Kim, Nenad Miljkovic   +6 more
wiley   +1 more source