Results 31 to 40 of about 55,349 (213)
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Attitude determination and control for centrifugal tether deployment on the ESTCube-1 nanosatellite; pp. 242–249 [PDF]
Proceedings of the Estonian Academy of Sciences, 2014 This paper presents the design, development, and pre-launch characterization of the ESTCube-1 Attitude Determination and Control System (ADCS). The design driver for the ADCS has been the mission requirement to spin up the satellite to 360 deg à sâ1 ...
Andris Slavinskis +22 more
doaj +1 more source
RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub +24 more
wiley +1 more source
Nature CommunicationsPrecision tumor theranostic in minimally invasive interventions still face challenges such as poor navigational flexibility and limited functional integration.
Fuqian Chen +13 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Factors associated with relapse course and disability in myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) remain incompletely understood. Objectives To identify clinical and modifiable factors associated with relapse and disability in MOGAD. Methods In this ambispective multicentre cohort study using data from
Yingtao Wang +23 more
wiley +1 more source
FS5 sun exposure survivability analysis
Terrestrial, Atmospheric and Oceanic Sciences, 2017 During the Acquisition and Safe Hold (ASH) mode, FORMOAT-5 (FS5) satellite attitude is not fully controlled. Direct sun exposure on the Remote Sensing Instrument (RSI) satellite telescope sensor may occur.
Ming-Ying Hsu +2 more
doaj +1 more source
Fabrication of Composite Microneedle Array Electrode for Temperature and Bio-Signal Monitoring
Sensors, 2018 Body temperature and bio-signals are important health indicators that reflect the human health condition. However, monitoring these indexes is inconvenient and time-consuming, requires various instruments, and needs professional skill.
Yiwei Sun +4 more
doaj +1 more source
Subjective Cognitive Concerns and Cognitive Trajectories in Parkinson's Disease: Biomarker Impact
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the relationship of subjective cognitive concerns (SCC) with biomarkers of Alzheimer's disease (AD), neurodegeneration, and Parkinson's disease (PD) and domain‐specific cognitive trajectories among cognitively unimpaired persons with de novo PD. Method Cognitively unimpaired participants with SCC (n = 294) and without SCC (
Francesca V. Lopez +5 more
wiley +1 more source
Nature CommunicationsPrecision and personalized medicine for disease management necessitates real-time, continuous monitoring of biomarkers and therapeutic drugs to adjust treatment regimens based on individual patient responses.
Jian Yang +8 more
doaj +1 more source