Results 31 to 40 of about 52,290 (257)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Magnetic-driven multifunctional optoelectronic catheter for in vivo chemical mapping and precisely guided-tumor therapy

Nature Communications
Precision tumor theranostic in minimally invasive interventions still face challenges such as poor navigational flexibility and limited functional integration.
Fuqian Chen, Xiaxu Liu, Yuanxi Zhang, Ying Zheng, Jingbo Yang, Tong Wu, Ke Zhao, Weiyuan Chen, Yuanyuan Li, Xia Gong, Hui Wang, Shuo Wu, Xi Xie, Lelun Jiang   +13 more
doaj   +1 more source

FS5 sun exposure survivability analysis

Terrestrial, Atmospheric and Oceanic Sciences, 2017
During the Acquisition and Safe Hold (ASH) mode, FORMOAT-5 (FS5) satellite attitude is not fully controlled. Direct sun exposure on the Remote Sensing Instrument (RSI) satellite telescope sensor may occur.
Ming-Ying Hsu, Shenq-Tsong Chang, Ting-Ming Huang   +2 more
doaj   +1 more source

Fabrication of Composite Microneedle Array Electrode for Temperature and Bio-Signal Monitoring

Sensors, 2018
Body temperature and bio-signals are important health indicators that reflect the human health condition. However, monitoring these indexes is inconvenient and time-consuming, requires various instruments, and needs professional skill.
Yiwei Sun, Lei Ren, Lelun Jiang, Yong Tang, Bin Liu   +4 more
doaj   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Microneedle-based integrated pharmacokinetic and pharmacodynamic evaluation platform for personalized medicine

Nature Communications
Precision and personalized medicine for disease management necessitates real-time, continuous monitoring of biomarkers and therapeutic drugs to adjust treatment regimens based on individual patient responses.
Jian Yang, Xia Gong, Ying Zheng, Hong Duan, Shuijin Chen, Tong Wu, Changqing Yi, Lelun Jiang, Hossam Haick   +8 more
doaj   +1 more source

Development of Ultra-Light 2-Axes Sun Sensor for Small Satellite [PDF]

Journal of Astronomy and Space Sciences, 2005
This paper addresses development of the ultra-light analog sun sensors for small satellite applications. The sun sensor is suitable for attitude determination for small satellite because of its small, light, low-cost, and low power consumption ...
Su-jeoung Kim, Sun-ok Kim, Byoung-Young Moon, Young-Keun Chang, Hwa-Suk Oh   +4 more
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source