Results 41 to 50 of about 1,329 (190)
Protein Science, Volume 35, Issue 10, October 2026.Abstract The rapid expansion of CRISPR technologies has unveiled a diverse repertoire of RNA‐guided endonucleases, among them the compact Cas12j, which has emerged as a promising genome‐editing tool. Cas12j cleaves the two DNA strands sequentially; however, the molecular mechanism that regulates this cleavage remains incompletely understood.
Ilias G. Karvounis, Vangelis Daskalakis
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Reaction–Diffusion and Diffusion‐Driven Fronts in Reversible Redox Autocatalytic Networks
ChemSystemsChem, Volume 8, Issue 5, September 2026.In addition to the autocatalytic reaction–diffusion oxidation front and the diffusive reduction front, a mixed‐type diffusion‐driven reduction front develops in the presence of oxygen, exhibiting characteristics of both front types. ABSTRACT Autocatalysis plays a critical role in the self‐organization of chemical and biological systems, influencing ...
Stevan Maćešić +2 more
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Clonal Mosaicism of Mitochondrial DNA Heteroplasmy as a Molecular Clock of Aging
Aging Cell, Volume 25, Issue 9, September 2026.Mitochondrial DNA mutations diverge by tissue dynamics across lifespan: dividing tissues accumulate pervasive point mutations via clonal stem‐cell expansion, whereas post‐mitotic tissues harbor clonally expanded large‐scale deletions, both culminating in age‐dependent, threshold‐limited respiratory failure.
Renin Chang +5 more
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The GLP‐1–Mitochondria Axis in Metabolic Aging
Aging Cell, Volume 25, Issue 8, August 2026.Glucagon‐like peptide‐1 receptor agonists engage AMPK–PGC‐1α signaling to remodel mitochondrial biogenesis, dynamics, and quality control, but downstream effects are context‐dependent and tissue‐specific rather than uniformly receptor‐proximal. Whether this proposed mitochondria‐incretin axis reflects a novel geroscience mechanism or indirect metabolic
Renin Chang +3 more
wiley +1 more source
compuGUT: An in silico platform for simulating intestinal fermentation
SoftwareX, 2017 The microbiota inhabiting the colon and its effect on health is a topic of significant interest. In this paper, we describe the compuGUT — a simulation tool developed to assist in exploring interactions between intestinal microbiota and their environment.
Arun S. Moorthy, Hermann J. Eberl
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A Study of the Yang-gyeong-gyu-il-ui (兩景揆日儀) in the Joseon Dynasty [PDF]
Journal of Astronomy and Space Sciences, 2015 The Yang-gyeong-gyu-il-ui (兩景揆日儀) is a kind of elevation sundial using three wooden plates. Sang-hyeok Lee (李尙爀, 1810~?) and Byeong-cheol Nam (南秉哲, 1817~1863) gave descriptions of this sundial and explained how to use it in their Gyu-il-go (揆日考) and Ui-
Yong Sam Lee +2 more
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Numerical Methods for Partial Differential Equations, Volume 42, Issue 4, July 2026.ABSTRACT While recent Anderson acceleration (AA) convergence theory [Pollock et al., IMA Num. An., 2021] requires that the AA optimization norm match the Hilbert space norm associated with the fixed point operator, in implementations the ℓ2$$ {\ell}^2 $$ norm is the most common choice. So far there is little research done regarding this discrepancy. To
Elizabeth Hawkins, Leo G. Rebholz
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Image of inverted World Tree on the stone slab and vessels of the Bronze Age [PDF]
Archaeoastronomy and Ancient Technologies, 2016 The article presents the results of the study of petroglyphs on a unique stone slab discovered near the kurgan 1 of the kurgan field Varvarinsky I (Rostov Oblast, Russia).
Vodolazhskaya, L.N. +2 more
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Improving the Numerical Solution of the Energy Equation in Land Models
Journal of Advances in Modeling Earth Systems, Volume 18, Issue 7, July 2026.Abstract The purpose of this study is to improve simulations of the energy equation in land models. Our objectives are to (a) highlight the shortcomings of current approaches for solving the energy equation in land models; (b) present improved solutions; and (c) evaluate tradeoffs between numerical errors and strict energy conservation in the energy ...
Ashley E. Van Beusekom +2 more
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Journal of Geophysical Research: Solid Earth, Volume 131, Issue 7, July 2026.Abstract The seismic expression of Earth's 410 km discontinuity varies across tectonic settings, from sharp, high‐amplitude interfaces to broad transitions—patterns that cannot be explained by equilibrium thermodynamics without invoking large‐scale thermal or compositional heterogeneities.
Buchanan Kerswell +5 more
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