Results 231 to 240 of about 84,765 (300)

Temporal variations and spatial clusters of diarrheal diseases before and during the COVID-19 pandemic in Jakarta province, Indonesia. [PDF]

BMC Public Health
Astutik E, Husnina Z, Yamani LN, Wangdi K.   +3 more
europepmc   +1 more source

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Management and outcomes of people presenting with new diabetes-related foot infections: a prospective observational study from Australia and New Zealand. [PDF]

BMJ Open Diabetes Res Care
Raby E, Manning L, McCarthy K, Hamilton EJ, Akram A, Bertschi N, Bhally H, Choong K, Donaldson A, Guy S, Lai K, Lemoh C, Lim LL, McGrath C, Mulo B, Otome O, Sehu M, Shum O, Vora P, Westphal C, Wong J, Lazzarini PA, Commons RJ, DINGO Study Group.   +23 more
europepmc   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Cold climate dual threats: lagged and nonlinear effects of air pollution and meteorological extremes on acute myocardial infarction risk. [PDF]

BMC Cardiovasc Disord
Xu H, Yin L, Zhang Y, Zhang H, Zhao H, Du K, Li M, Yu D, Dong K, Peng S, Sun Y, Song T.   +11 more
europepmc   +1 more source

Synergistic Sunlight‐Activated Photodynamic and Near‐Infrared‐Induced Mild Photothermal Therapy for Infected Wound Healing Using Functionalized Nano‐Bi2WO6 Composites

Advanced Science, EarlyView.
This work proposes a multifunctional Bi2WO6:Yb,Er@CuS@CS nanocomposite that integrates photodynamic therapy (PDT), near‐infrared‐triggered photothermal therapy (PTT), and Cu2+ release for infected wound repair. The nanocomposite demonstrates enhanced antibacterial efficacy via combined PDT, PTT, and Cu2+ release, effective immunomodulatory by mild ...
Yihao Sun, Liangrui He, Zhijun Shen, Yuxin Zhang, Yizhang Tang, Xujiang Yu, Jisi Zheng, Moran Huang, Wanwan Li, Lei Wang   +9 more
wiley   +1 more source

Advanced machine learning framework for thyroid cancer epidemiology in Iran through integration of environmental socioeconomic and health system predictors. [PDF]

Sci Rep
Soleimani M, Chiti H.
europepmc   +1 more source

Analysis of sunshine duration and surface temperature of a building in urban areas using a sunshine duration model and easurements

Journal of the Geological Society of Korea
Jung-Eun Kang, Ju-Hwan Rho, Ji-Eun Lee, Sung-hee Kim, Chae-Rin Kim, Jeong-Min Son, Min-Jae Jo, Eun-Seo Jo, Soo-Jin Park, Jae-Jin Kim   +9 more
openaire   +1 more source

m5C‐Modified tRF3b‐CysGCA‐23 Suppresses Bladder Cancer Malignancy by Repressing H3K18 Lactylation via Stabilizing RBM4

Advanced Science, EarlyView.
In this study, we identified an NSUN6‐dependent m5C‐modified tsRNA, m5C‐tRF3b CysGCA‐23 (mtRC), that is downregulated in BC and inversely correlated with disease progression. Mechanistically, mtRC suppresses BC malignancy by stabilizing RBM4, attenuating glycolysis, and thereby limiting H3K18 lactylation–mediated activation of IL1RAP and VASH2 ...
Xiaoling Ying, Yapeng Huang, Jian Huang, Qinyu Cai, Danni Zhang, Cong Chen, Yuxi Nie, Baotong Yang, Chuan Li, Wenyu Hu, Chang Xiong, Chengcheng Zhang, Ding Ji, Yaomin Liang, Mei Yang, Wenqi Wu, Weidong Ji   +16 more
wiley   +1 more source

Excavation and effect analysis of interaction sites between upland cotton yield and fiber quality traits and environmental factors. [PDF]

BMC Plant Biol
Yao S, Gong J, Gong W, Li Y, Pan J, Shi Y, Yuan Y, Yan H, Shang H.   +8 more
europepmc   +1 more source