Status Epilepticus and Beyond: A Clinical Review of Status Epilepticus and an Update on Current Management Strategies in Super-refractory Status Epilepticus [PDF]
, 2017 Status epilepticus and refractory status epilepticus represent some of the most complex conditions encountered in the neurological intensive care unit. Challenges in management are common as treatment options become limited and prolonged hospital courses
Roy Poblete, Gene Sung
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The Journal of Clinical Pharmacology, Volume 66, Issue 6, June 2026.Abstract Ketamine is a non‐competitive antagonist at the N‐methyl‐D‐aspartate (NMDA) glutamate receptor. It was approved by the US Food and Drug Administration for anesthesia in 1970. The only other related US regulatory approval since then has been for esketamine nasal spray for depression in 2019. Over this time ketamine has been repurposed by mainly
Paul Glue, Ben Beaglehole
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Vagus Nerve Stimulation (VNS) in Super Refractory New Onset Refractory Status Epilepticus (NORSE)
, 2019 The treatment protocol of status epilepticus has many associated toxicities so there is interest in alternate nonmedicinal therapies for managing New Onset Refractory Status Epilepticus (NORSE) patients.
Mohankumar Kurukumbi +3 more
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Rapid recovery after intrathecal dexamethasone in FIRES
Epileptic Disorders, Volume 28, Issue 3, Page 884-887, June 2026.
João Filipe Nico +8 more
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Refractory and super-refractory status epilepticus in adults: a 9-year cohort study.
, 2017 While status epilepticus (SE) persisting after two antiseizure agents is called refractory (RSE), super-refractory status epilepticus (SRSE) defines SE continuing after general anaesthesia.
Marchi, N.A. +4 more
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First‐in‐man allopregnanolone use in super‐refractory status epilepticus
, 2017 Super‐refractory status epilepticus (SRSE) is associated with high morbidity and mortality. Treatment of SRSE is complicated by progressive cortical hyperexcitability believed to result in part from synaptic GABA receptor internalization and ...
Cole, Andrew +7 more
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NORSE and Super-Refractory Status Epilepticus: a Single-Center Retrospective Chart Review
, 2018 Rationale: New-Onset Refractory Status Epilepticus (NORSE) is a rare life-threatening condition in previously healthy patients who develop new-onset medically-refractory status epilepticus of unclear etiology.1NORSE commonly leads to super-refractory ...
Rezayee, Manaz
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Treatment of convulsive status epilepticus in Brazil: a review
Arquivos de Neuro-PsiquiatriaStatus epilepticus (SE) is the most severe presentation of epilepsy. Currently, SE is defined according to 2 sequential time frames: time 1, after which it is unlikely that the seizure will resolve spontaneously, therefore requiring the initiation of ...
Luis Otavio Caboclo
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Commentary on Isoflurane in Refractory and Super-Refractory Status Epilepticus [PDF]
Neurocritical Care, 2021 openaire +3 more sources
Vagus nerve stimulation in refractory and super-refractory status epilepticus - A systematic review
, 2019 RATIONALE: Refractory status epilepticus (RSE) is the persistence of status epilepticus despite second-line treatment. Super-refractory SE (SRSE) is characterized by ongoing status despite 48 h of anaesthetic treatment.
Dibué-Adjei, Maxine +4 more
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