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Refractory and Super-Refractory Status Epilepticus—an Update
Current Neurology and Neuroscience Reports, 2014Status epilepticus is a medical emergency with a high mortality. Early recognition and initiation of treatment leads to a better response and may improve outcomes. Refractory status epilepticus is defined as recurrent seizure activity despite two appropriately selected and dosed antiepileptic drugs including a benzodiazepine. The term "super-refractory
Sara Hocker, William O Tatum
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Continuum, 2022
Status epilepticus is a serious condition caused by disorders and diseases that affect the central nervous system. In status epilepticus, hypersynchronous epileptic activity lasts longer than the usual duration of isolated self-limited seizures (time t1), which causes neuronal damage or alteration of neuronal networks at a certain time point (time t2),
Eugen, Trinka, Markus, Leitinger
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Status epilepticus is a serious condition caused by disorders and diseases that affect the central nervous system. In status epilepticus, hypersynchronous epileptic activity lasts longer than the usual duration of isolated self-limited seizures (time t1), which causes neuronal damage or alteration of neuronal networks at a certain time point (time t2),
Eugen, Trinka, Markus, Leitinger
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Neuromodulation in Super-refractory Status Epilepticus
Journal of Clinical Neurophysiology, 2021Summary: Status epilepticus (SE) is a severe condition that needs immediate pharmacological treatment to tackle brain damage and related side effects. In approximately 20% of cases, the standard treatment for SE does not control seizures, and the condition evolves to refractory SE.
Ioannis, Stavropoulos +2 more
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Status Epilepticus, Refractory Status Epilepticus, and Super-refractory Status Epilepticus
Continuum, 2018Status epilepticus, refractory status epilepticus, and super-refractory status epilepticus can be life-threatening conditions. This article presents an overview of the three conditions and discusses their management and outcomes.Status epilepticus was previously defined as lasting for 30 minutes or longer but now is more often defined as lasting 5 ...
Sarah E, Nelson, Panayiotis N, Varelas
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Brain, 2012 In a previous paper, we reviewed the range of therapies available for the treatment of super-refractory status epilepticus. Here we report a review of the outcome of therapies in refractory and super-refractory status epilepticus. Patients (n = 1168) are
Simon Shorvon +2 more
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Status epilepticus: Refractory and super-refractory
Neurology India, 2017Status epilepticus (SE) is an important neurological emergency. It is defined as seizures lasting for 5 minutes or more or recurrent seizures without recovery of consciousness to baseline between the attacks. Refractory SE (RSE) is defined as SE persisting despite sufficient dose of benzodiazepines and at least one antiepileptic drug (AED ...
Deepanshu, Dubey +2 more
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Predictors of outcome in super refractory status epilepticus
Epilepsy & Behavior, 2021We conducted this study to determine the clinical, electrophysiological and radiological predictors of outcome in Super Refractory Status Epilepticus (SRSE).Data of patients treated for SRSE between January 2000 and November 2019, archived prospectively in our SE registry were analyzed.
Jithu Jose +6 more
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Treatment of Super-Refractory Status Epilepticus
Current Neurology and Neuroscience Reports, 2015Super-refractory status epilepticus (SRSE) is a devastating neurological condition with limited treatment options. We conducted an extensive literature search to identify and summarize the therapeutic options for SRSE. The search mainly resulted in case reports of various pharmacologic and non-pharmacologic treatments.
Ahmad, Bayrlee +3 more
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Super-refractory status epilepticus in West China
Acta Neurologica Scandinavica, 2014This study aims to determine the general frequency, mortality, and risk factors of super-refractory status epilepticus (SRSE) versus non-refractory status epilepticus (NRSE) and refractory status epilepticus (RSE).This work is a retrospective study. Clinical data of patients who were diagnosed with status epilepticus (SE) in the neurological ward and ...
L, Tian +6 more
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Electroconvulsive Therapy for Super Refractory Status Epilepticus
The Journal of ECT, 2018Objectives Super refractory status epilepticus (SRSE) is a stage beyond refractory status that requires general anesthesia as management. Electroconvulsive therapy (ECT) is recommended only as a potential treatment option beyond general anesthesia and after all other options have been exhausted.
Jayme, Ahmed +8 more
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