Engineering Antibody Evolution: Germline‐Targeting HIV Vaccines Reach a Turning Point
This commentary examines three recent Nature studies demonstrating a conceptual shift in HIV vaccine design, demonstrating how germline‐targeting HIV vaccines can progress beyond expanding rare broad neutralizing antibody (bnAb) precursors to deliberately guiding their affinity maturation into bnAbs in non‐human primates.
Rowena A. Bull, Deborah L. Burnett
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The sim gene of Escherichia coli phage P1: nucleotide sequence and purification of the processed protein [PDF]
Maillou J, Dreiseikelmann B. The sim gene of Escherichia coli phage P1: nucleotide sequence and purification of the processed protein. Virology. 1990;175(2):500-507.The sim gene of bacteriophage P1 causes exclusion of a superinfecting P1 phage.
Maillou, Julia +3 more
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RSV Disease Among Hospitalized Children: Second vs. First Year of Life Multicenter Study
ABSTRACT Background Respiratory syncytial virus (RSV) is a leading cause of pediatric hospitalization, yet data on children hospitalized with RSV in their second year of life are limited. Objective To compare clinical characteristics and management practices of children hospitalized with RSV during their second versus first year of life.
Keren Armoni Domany +17 more
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Human immunodeficiency virus type 1 clade B superinfection:Evidence for differential immune containment of distinct clade B strains [PDF]
Sequential infection with different strains of human immunodeficiency virus type 1 (HIV-1) is a rarely identified phenomenon with important implications for immunopathogenesis and vaccine development.
Yang, Otto O +19 more
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Corynebacterium pseudodiphtheriticum is a Gram-positive bacterium found as a member of the normal microbiota of the upper respiratory tract. It was suggested that C.
P. Kanmani +8 more
semanticscholar +1 more source
Expert consensus on oral management in autoimmune bullous diseases, erythema multiforme and SJS/TEN
This international Delphi study achieved expert consensus on 58 statements guiding the management of oral involvement in autoimmune bullous diseases, erythema multiforme and SJS‐TEN. The recommendations emphasize multidisciplinary care, oral hygiene and tailored topical, systemic and inpatient oral management.
Shalini Nayee +39 more
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Superinfection and cell regeneration can lead to chronic viral coinfections
Highlights • Clinical researchers have found that coinfection of the respiratory tract can cause distinct disease outcome, sometimes leading to long-lasting infection, compared to single viral infection.• The impact of coinfections in human respiratory ...
L. Pinky +2 more
semanticscholar +1 more source
Long‐Term Care of OLP Patients: A Retrospective Study From a Single Hospital Outpatient Clinic
ABSTRACT Background Oral lichen planus (OLP) is a chronic immune‐mediated disorder with malignant potential. However, its real‐world clinical course remains incompletely characterized. This study aimed to describe the natural clinical–histopathological trajectory of OLP in a single tertiary centre and to identify factors associated with dysplasia and ...
F. Scilla +8 more
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Mycobacteriophage Fruitloop gp52 inactivates Wag31 (DivIVA) to prevent heterotypic superinfection
Bacteriophages engage in complex dynamic interactions with their bacterial hosts and with each other. Bacteria have numerous mechanisms to resist phage infection, and phages must co‐evolve by overcoming bacterial resistance or by choosing an alternative ...
Ching-Chung Ko, G. Hatfull
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Superinfection Exclusion in Cells Infected with Hepatitis C Virus [PDF]
Superinfection exclusion is the ability of an established virus infection to interfere with infection by a second virus. In this study, we found that Huh-7.5 cells acutely infected with hepatitis C virus (HCV) genotype 2a (chimeric strain J6/JFH) and ...
Evans, MJ +7 more
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