Results 121 to 130 of about 2,003 (257)

With a Great Story Comes Great Responsibility: Role of Narrative in Leadership Development. [PDF]

New Dir Stud Leadersh
Connable S.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Impact of the Abdominal Drawing-In Maneuver on Spinal Extensor Muscle Activity: A Randomized Controlled Double-Blind Trial Involving Individuals with Non-Specific Low Back Pain. [PDF]

Int J Environ Res Public Health
Soylu C, Atalay ES, Turker D, Sahan TY, Un Yildirim N.   +4 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Narrative-driven virtual reality serious game to support type 1 diabetes self-management in children. [PDF]

Sci Rep
Gu H, Mohd Muhaiyuddin NDB, Shaari NB.
europepmc   +1 more source

Becoming Superman: Interpolating Transsexuality into the Superman Narrative

, 2013
Reflecting the masculine ethos of the larger comic book industry, superhero comics continue to be male-dominated spaces. Within comic studies, superhero scholars problematically normalize this androcentrism by reiterating the genre’s masculinist rhetoric, repeatedly positioning superheroes as stoic figures of whiteness, nationhood, heteronormativity ...
openaire   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

High-Resolution 3D Turbo Spin-Echo Wrist MRI at 7T Accelerated by Compressed Sensing. [PDF]

NMR Biomed
Runderkamp BA, Caan MWA, van der Zwaag W, Hemke R, Maas M, Andersen M, Strijkers GJ, Markenroth Bloch K, Nederveen AJ.   +8 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

SUPERMAN requires its EAR motif to recruit the corepressor TOPLESS and to function as a cadastral regulator in floral patterning. [PDF]

BMC Plant Biol
Wokasch AS, Albanese O, Terao J, Yamadi M, Deneen A, Bastin A, Palau SI, Calvo Palacios J, Foege CS, Coulibaly MR, Krogan NT.   +10 more
europepmc   +1 more source