Results 141 to 150 of about 6,407 (247)

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Shaw\u27s Man and Superman and the Don Juan Legend

open access: yes
As seen from the point of view of the dramatist Bernard Shaw, Don Juan is portrayed in his play Man and Superman as a public figure of a womanizer who has appeared in multiple literary works.
Khalid Almukhtar , Ali, Kamil, Manar
core   +1 more source

Mechanism design and human-machine coupling analysis for a lumbar rehabilitation robot. [PDF]

open access: yesFront Bioeng Biotechnol
Tian Y   +5 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Man and Superman, 1952

open access: yes, 1952
Mask and Mantle presents "Man and Superman" by George Bernard Shaw.
Mask and Mantle, Earlham College
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

US vs. THEM : a critical analysis of superman - Peace on Earth [PDF]

open access: yes, 2002
Veloso, Francisco Osvanilsom Dourado
core  

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