Results 181 to 190 of about 874,608 (238)

Complex small supernumerary marker chromosome with a 15q/16p duplication: clinical implications. [PDF]

Mol Cytogenet, 2014
Christofolini DM, Piazzon FB, Evo C, Mafra FA, Cosenza SR, Dias AT, Barbosa CP, Bianco B, Kulikowski LD.   +8 more
europepmc   +1 more source

Late INa as a Therapeutic Target: New Strategies, Computational Modelling, Drug Development, and Clinical Translation

Medicinal Research Reviews, Volume 46, Issue 6, Page 1939-1957, November 2026.
ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay, Lynn C. Lunsonga, Peter E. Light, Khaled Barakat   +3 more
wiley   +1 more source

Auxin‐related regulation of barley floral organ fate: genetic and phenotypic insights from tweaky spike mutants

New Phytologist, Volume 252, Issue 3, Page 1166-1180, November 2026.
Inflorescence/floret phenotypes of tweaky spike (tw) barley (Hordeum vulgare) mutants and their respective WT backgrounds. Summary Mutant‐based research is a cornerstone for elucidating gene function in barley (Hordeum vulgare) and other cereals. In this study, we exploited a unique collection of barley tweaky spike (tw) mutants to identify the locus ...
Vėjūnė Pukenytė, Bernadeta Kaminskaitė‐Mačė, Miglė Remeikytė, Jurga Jankauskienė, Julius Juodakis, Sigita Jurkonienė, Algė Leistrumaitė, Ljudmilla Timofejeva, Virginija Vaitkūnienė, Justas Stonkus, Raimondas Šiukšta   +10 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, Volume 20, Issue 10, Page 2490-2509, October 2026.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

From Genomics to Precision Cardiology: A Comprehensive Review of Clinical Applications and Challenges in Cardiovascular Diseases

Clinical Cardiology, Volume 49, Issue 10, October 2026.
Genomic medicine in cardiovascular care is progressing from established diagnostic applications toward integrated risk prediction, multiomics, and emerging therapeutic strategies. ABSTRACT Background Genomic cardiology is an emerging field integrating genetic, molecular, imaging, and digital health data to improve cardiovascular disease (CVD ...
Neda Mohsen‐Pour, Shiva Esmaeili, Aydin Feyzi, Ali Sharafi, Majid Maleki, Samira Kalayinia   +5 more
wiley   +1 more source

Integrating Multimodal MRI Habitat and Transformer‐Based Pathomics to Predict High‐Risk Molecular Subtypes and Explore Biological Mechanisms in Adult Diffuse Gliomas

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Based on the 2021 WHO CNS5 guidelines, this study introduces an integrated high‐risk molecular classification for gliomas and constructs a predictive model by combining multimodal MRI habitat imaging, Transformer‐based WSI pathomics, and clinical information.
Wenju Niu, Xin Duan, Xuan Li, Zehui Li, Qian Liang, Xiangli Yang, Yan Tan, Xiaochun Wang, Guoqiang Yang, Hui Zhang   +9 more
wiley   +1 more source

B chromosomes put the 'super' in supernumerary. [PDF]

Trends Genet
Samuelson KB, Hanlon SL.
europepmc   +1 more source

Prenatal diagnosis and genetic counseling in a fetus associated with risk of Angelman syndrome with a small supernumerary marker chromosome derived from chromosome 22. [PDF]

Mol Cytogenet, 2016
Hu YA, Cui Y, Fan X, Wu Q, Li W, Wang W.
europepmc   +1 more source

Cat Eye Syndrome in a Sudanese Infant: Congenital Cataract in the Absence of Iris Coloboma: A Case Report. [PDF]

Clin Case Rep
Khalid R, Fadl-Elmula I.
europepmc   +1 more source

Helicobacter pylori Outer Membrane Vesicles Engage TLR2 Through NapA to Promote Epithelial Association and Inflammatory Signalling

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
ABSTRACT Helicobacter pylori infection is characterized by chronic gastric inflammation driven by persistent activation of innate immune signalling pathways. Outer membrane vesicles (OMVs) released by H. pylori are important mediators of host–pathogen interactions. Although several mechanisms of OMV internalization have been described, how specific OMV‐
Mariaignacia Rubilar, Rosy Brito, Annegrett Palavecino, Joan Villena, Marco Mellado, María I. Silva, Manuel Valenzuela‐Valderrama   +6 more
wiley   +1 more source