Results 51 to 60 of about 149,837 (302)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The Closure Operator with the Equality Predicate Branching on the Set of Hyperfunctions on Two-Element Set

Известия Иркутского государственного университета: Серия "Математика", 2014
In this work we consider the closure operator with the equality predicate branching (E-operator) on the set of hyperfunctions on two-element set. With respect to this operator closed classes of hyperfunctions are generated.
V.I. Panteleev, L.V. Ryabets
doaj  

Nonadiabatic dynamics with classical trajectories: The problem of an initial coherent superposition of electronic states.

, 2023
Advances in coherent light sources and development of pump-probe techniques in recent decades have opened the way to study electronic motion in its natural time-scale.
Federica, Agostini, Neepa, Maitra, Evaristo, Villaseco Arribas   +2 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Quantum-Enhanced K-Medoids Clustering: Comparative Analysis of Stroke Medical Data

Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi)
Stroke is a severe medical condition that occurs when the blood supply to parts of the brain is interrupted or reduced, resulting in brain tissue that lacks oxygen and nutrients. This causes brain cells to start to die in minutes.
Ricardo Siahaan, Swingly Purba, Jeremia Siregar, Marvin Frans Sakti Hutabarat, Rasmi Sitohang   +4 more
doaj   +1 more source

Topological charge of superposition of optical vortices described by a geometric sequence

Компьютерная оптика, 2022
Here, we investigate coaxial superpositions of Gaussian optical vortices that can be described by a geometric sequence. For all superpositions analyzed, a topological charge (TC) is derived.
V.V. Kotlyar, A.A. Kovalev
doaj   +1 more source

Online sensor testing through superposition of encoded stimulus. [PDF]

, 2007
Online monitoring remains an important requirement for a range of microsystems. The solution based on the injection of an actuating test stimulus into the bias structure of active devices holds great potential.
Bunyan, J., Richardson, A., Richardson, Andrew, Dumas, Norbert, Xu, Zhou, Georgopoulos, Kostas, Xu, Z., Georgopoulos, K., Bunyan, John, Dumas, N.   +9 more
core  

Intensity improvement in the attosecond pulse generation with the coherent superposition initial state

, 2012
We investigate the coherent superposition initial state effect and found that when the initial active electron state is prepared in the coherent superposition of the is and 2s states of the He+ ion and the chirp parameter of the fundamental field in the ...
楚天舒, Chu, Tianshu, Feng, Liqiang
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Orbital angular momentum of superpositions of optical vortices after passing through a sector diaphragm

Компьютерная оптика, 2022
In optical communications, it is desirable to know some quantities describing a light field, that are conserved on propagation or resistant to some distortions. Typically, optical vortex beams are characterized by their orbital angular momentum (OAM) and/
A.A. Kovalev
doaj   +1 more source