Results 61 to 70 of about 752,283 (330)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Comparison Between Supervised and Unsupervised Classifications of Neuronal Cell Types: A Case Study

, 2010
In the study of neural circuits, it becomes essential to discern the different neuronal cell types that build the circuit. Traditionally, neuronal cell types have been classified using qualitative descriptors.
Bielza, Concha, Guerra, Luis, Larrañaga Múgica, Pedro, McGarry, Laura M., Robles Forcada, Víctor, Yuste, Rafael   +5 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

MalSSL—Self-Supervised Learning for Accurate and Label-Efficient Malware Classification

IEEE Access
Malware classification with supervised learning requires a large dataset, which needs an expensive and time-consuming labeling process. In this paper, we explore the efficacy of self-supervised learning techniques for malware classification.
Setia Juli Irzal Ismail, Hendrawan, Budi Rahardjo, Tutun Juhana, Yasuo Musashi   +4 more
doaj   +1 more source

Classification Algorithm and Application Based on Semi-Supervised Deep Auto-Encoder Network [PDF]

Jisuanji gongcheng
In industrial classification prediction, labeled data are scarce, and labeling is expensive, leading to inaccurate model predictions. Simultaneously, features in most unlabeled data are not effectively used, resulting in insufficient generalization of ...
ZHANG Xinbo, ZHANG Xueying, HUANG Lixia, CHEN Guijun
doaj   +1 more source

Tree Species Classification Based on Self-Supervised Learning with Multisource Remote Sensing Images

Applied Sciences, 2023
In order to solve the problem of manual labeling in semi-supervised tree species classification, this paper proposes a pixel-level self-supervised learning model named M-SSL (multisource self-supervised learning), which takes the advantage of the ...
Xueliang Wang, Nan Yang, Enjun Liu, Wencheng Gu, Jinglin Zhang, Shuo Zhao, Guijiang Sun, Jian Wang   +7 more
doaj   +1 more source

Supervised Blockmodelling

, 2012
Collective classification models attempt to improve classification performance by taking into account the class labels of related instances. However, they tend not to learn patterns of interactions between classes and/or make the assumption that ...
Peel, Leto
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

SPEMix: a lightweight method via superclass pseudo-label and efficient mixup for echocardiogram view classification

Frontiers in Artificial Intelligence
IntroductionIn clinical, the echocardiogram is the most widely used for diagnosing heart diseases. Different heart diseases are diagnosed based on different views of the echocardiogram images, so efficient echocardiogram view classification can help ...
Shizhou Ma, Yifeng Zhang, Delong Li, Yixin Sun, Zhaowen Qiu, Lei Wei, Suyu Dong   +6 more
doaj   +1 more source