Results 211 to 220 of about 934,428 (242)

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

Aberrant Splicing Signatures Underpin Oligodendrocyte Damage in ALS and Neuron Loss in FTD

Advanced Science, EarlyView.
Integrating bulk and single‐nucleus RNA‐seq from ALS and FTD patients, we revealed distinct cellular dysfunctions, with severe oligodendrocyte damage in ALS and pronounced neuron loss in FTD. We identified cell‐type‐specific aberrant splicing events as potential biomarkers with robust classification performance, some of which produce de novo peptides ...
Chen Du, Yinming Li, Rong Wu, Yufei Shen, Jiayi Yang, Xuan Xiao, Yu Zhou   +6 more
wiley   +1 more source

Artificial Intelligence in Ocular Transcriptomics: Applications of Unsupervised and Supervised Learning. [PDF]

Cells
Lalman C, Yang Y, Walker JL.
europepmc   +1 more source

Subclass-Aware Contrastive Semi-Supervised Learning for Inflammatory Bowel Disease Classification from Colonoscopy Images. [PDF]

Bioengineering (Basel)
Lin K, Ruan G, Zou X, Nian Y, Wei Y, Zheng G.   +5 more
europepmc   +1 more source

Multimodal Self-Supervised Learning for Early Alzheimer's: Cross-Modal MRI-PET, Longitudinal Signals, and Site Invariance. [PDF]

Diagnostics (Basel)
Ali SB, Ghannam NE, Mancy H, Elkilany BG.   +3 more
europepmc   +1 more source

Data-Efficient Deep Learning Framework for Urolithiasis Detection Using Transfer and Self-Supervised Learning. [PDF]

Int Neurourol J
Kim JS, Eun SJ.
europepmc   +1 more source

River extraction from high-resolution remote sensing images based on non-uniform sampling and semi-supervised learning. [PDF]

Sci Rep
Wang K, Han L, Li L.
europepmc   +1 more source

Self-supervised learning with BYOL for anterior cruciate ligament tear detection from knee MRI. [PDF]

MethodsX
Aidarkhan A, Mukhamediya A, Askhatova A, Beisembekova R, Alimbayeva Z, Ozhikenova A, Ozhikenov K, Jamwal PK.   +7 more
europepmc   +1 more source