Results 121 to 130 of about 2,296,173 (238)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Grado de supervisión entre liderazgo y satisfacción del personal ejecutivo comercial del Banco Falabella Open Plaza Chiclayo [PDF]
, 2017 La presente investigación se desarrolla sobre la Empresa Banco Falabella Chiclayo, específicamente en la sucursal Open Plaza. La investigación nace a partir de la intención de medir la satisfacción laboral de los encargados de la parte comercial del ...
Moncayo Ylma, Claudia Paola +1 more
core +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Scientific ReportsThe use of amendments in combination with Bacillus subtilis has been understudied as a strategy for rehabilitating acid soils and improving cropping systems. This study aimed to evaluate the effects of amendments and B. subtilis on the development, yield,
Henry Diaz-Chuquizuta +7 more
doaj +1 more source
Dime cómo evalúas( en la universidad) y te diré qué tipo de profesional (y de persona) eres [PDF]
, 2001 En este trabajo se aporta un análisis crítico de cómo se realiza la evaluación en la Universidad, condicionada por prescripciones legales, supervisión institucional, presiones sociales y condiciones organizativas.
Santos Guerra, Miguel Ángel
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Diseño e implementación de la supervisión, el control y la simulación de un proceso químico [PDF]
, 2017 Dentro del contexto de la Automatización Industrial se encuentran los sistemas de información y comunicación Industriales, los cuales permiten el desarrollo y la mejora de infinidad de procesos industriales. Con esto se consiguen mejoras en la producción
Pamplona Pérez, Oriol
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source