Results 131 to 140 of about 2,351,817 (237)
Diseño e implementación de la supervisión, el control y la simulación de un proceso químico [PDF]
, 2017 Dentro del contexto de la Automatización Industrial se encuentran los sistemas de información y comunicación Industriales, los cuales permiten el desarrollo y la mejora de infinidad de procesos industriales. Con esto se consiguen mejoras en la producción
Pamplona Pérez, Oriol
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Acción y Reflexión Educativa, 2016 Este escrito presenta, de manera muy general, la génesis y la evolución de la Revista Especializada Acción y Reflexión Educativa que publica, desde 1978, el Instituto Centroamericano de Administración y Supervisión de la Educación (ICASE) de la ...
Magda Lida Jurado
doaj
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
El proceso de acreditación en Panamá
Acción y Reflexión Educativa, 2016 El proceso de acreditación como mecanismo de eficiencia y eficacia en el nivel superior, llegó a Panamá con mayor fuerza en los años 90 del Siglo XX.
Gladys Correa
doaj