Results 91 to 100 of about 2,499,874 (283)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
The death of reflective supervision? An exploration of the role of reflection within supervision in a Local Authority Youth Offending Service [PDF]
, 2014 Reflection within supervision has been identified as key to effective social work practice (Munro, 2011). However, despite the tradition of supervision being strongly embedded in youth justice practice, other imperatives, such as audit monitoring and ...
Taylor, Rhian
core
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Scientific ReportsAI-based cervical lesion segmentation in colposcopy images has significant potential in improving screening efficiency and accuracy. However, most current cervical lesion segmentation algorithms are insufficient for rapid image segmentation in mass ...
Jiahui Yang +7 more
doaj +1 more source
, 2005 Vor dem Hintergrund stress- und ressourcentheoretischer Überlegungen werden in einer Fragebogenstudie (N = 110) bei MitarbeiternInnen ambulanter psychiatrischer Einrichtungen die Effekte von Supervision auf die Entwicklung beruflicher Ressourcen ...
Eichert, Hans-Christoph
core +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
, 2003 Die vorliegende Arbeit ist eine repräsentative Vergleichsstudie zwischen Profit- und Non-Profit-Organisationen/Institutionen in den sechs Branchensegmenten Industrie, Verwaltung, Verkehr, Gewerbe, Unterrichtswesen und Gesundheits- und Sozialwesen in der ...
Disler, T.
core +1 more source