Results 111 to 120 of about 2,818,371 (325)

Supervision Quartets [PDF]

Postgraduate Medical Journal, 2012
openaire   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Vorwort

Forum Supervision, 2020
Forum Supervision
doaj   +1 more source

Enabling On-Device Large Language Model Personalization with Self-Supervised Data Selection and Synthesis [PDF]

, 2023
Ruiyang Qin, Jun Xia, Zhenge Jia, Meng Jiang, Ahmed Abbasi, Peipei Zhou, Jingtong Hu, Yiyu Shi   +7 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

A novel lightweight multi-scale feature fusion segmentation algorithm for real-time cervical lesion screening

Scientific Reports
AI-based cervical lesion segmentation in colposcopy images has significant potential in improving screening efficiency and accuracy. However, most current cervical lesion segmentation algorithms are insufficient for rapid image segmentation in mass ...
Jiahui Yang, Ying Zhang, Wenlong Fan, Jie Wang, Xinhe Zhang, Chunhui Liu, Shuang Liu, Linyan Xue   +7 more
doaj   +1 more source

Efficiently enforcing mutual state exclusion requirements in symbolic supervisor synthesis

, 2021
Sander Thuijsman, Michel Reniers, Dennis Hendriks   +2 more
openalex   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Autor_innenverzeichnis

Forum Supervision, 2019
Redaktion Supervision
doaj   +3 more sources

Investigation and analysis of allergen labeling in prepackaged food in China

Zhongguo shipin weisheng zazhi
ObjectiveTo investigate the current status of allergen labeling in prepackaged food products in China.MethodsA total of 986 prepackaged foods in 18 categories were from 26 provinces （autonomous regions， centrally administered municipalities） randomly ...
WANG Dan, LI Hejing, XUE Chenyu, YANG Honglian, LI Enjing, WANG Liping, MU Tongna, YIN Huatao   +7 more
doaj   +1 more source