Results 91 to 100 of about 127,847 (301)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Supervisory management

Education + Training, 1978
The Supervisor is one of the most significant employees in an organisation. He is in reality the first level of management with the closest interface with the bulk of the staff, yet regrettably he is often not given the status or support which is needed to make him truly effective. Supervisors' jobs are not easy, whether in production or in the office.
openaire   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Market newsletter 3/2015 [PDF]

, 2016
Topical matters at ESMA 1 Market manipulation – what it includes 2 Procedures relating to application of the Market Abuse Regulation 3 Forthcoming changes to prospectus regulations regarding securities offerings and listings 4 Examples of the ...

core  

Tax wedge in Croatia, Italy, Ireland, the Netherlands and Spain

Financial Theory and Practice, 2016
Each country has a unique tax system, comprising a number of components reflecting the taxation and economic policy of a country. The aim of this paper is to analyse and compare the tax burden on labour income in Croatia, Italy, Spain, Ireland and the ...
Maja Cundić
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The relationship of communication skills with leadership style and conflict management strategies of head nurses: A cross-sectional study in Northern Iran [PDF]

Journal of Research Development in Nursing and Midwifery
Background: Head nurses, as operational managers of hospitals, require robust communication skills, comprehensive leadership knowledge, and proficient conflict management strategies.
Alireza Heidari, Sakine Beygom Kazemi, Mohammad Javad Kabir, Zahra Khatirnamani, Mansoureh Lotfi, Narges Rafiei, Mahla Tajari, Sakine Jafar, Farah Zanganeh   +8 more
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

RESTRUKTURIRANJE DRUŠTAVA U POTEŠKOĆAMA I TRŽIŠTE KAPITALA – VRSTE I UPRAVLJANJE SUKOBOM INTERESA

Zbornik Pravnog Fakulteta Sveučilišta u Rijeci, 2018
Predmet rada je istražiti na koji način tržište kapitala može biti platforma za restrukturiranje društava u poteškoćama te koji su financijski posrednici tipično uključeni u te postupke. Nakon toga analizirat će se sukobi interesa koji se mogu pojaviti u
Morana Derenčinović Ruk
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source