Results 51 to 60 of about 91,010 (309)

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Estimation of Effects of Recent Macroprudential Policies in a Sample of Advanced Open Economies

open access: yesInternational Journal of Financial Studies, 2019
We used a time-series cross-section dataset to test several hypotheses pertaining to the role of macroprudential policy instruments in the management of the financial cycle in advanced open economies.
Ragnar Nymoen   +2 more
doaj   +1 more source

Predictive accuracy of option pricing models considering high-frequency data

open access: yesEkonomski Vjesnik, 2021
Purpose: Recently, considerable attention has been given to forecasting, not only the mean and the variance, but also the entire probability density function (pdf) of the underlying asset.
Josip Arnerić, Maria Čuljak
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

The conflict in the nurse managing exercise in hospital context – preview note.

open access: yesOnline Brazilian Journal of Nursing, 2008
This work is the result of a masters dissertation project developed in Post-Graduation Program in Nursing from the Federal University of Santa Maria (UFSM).
Soeli Teresinha Guerra   +1 more
doaj  

Financial stability indicator for non-banking markets [PDF]

open access: yesRevista de Studii Financiare, 2020
A mixed frequency indicator is designed to incorporate and extract information from time-series data that are available at different frequencies: daily, monthly, quarterly, etc.
Marius Cristian Acatrinei
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Progressive events in supervisory control and compositional verification

open access: yes, 2014
This paper investigates some limitations of the nonblocking property when used for supervisor synthesis in discrete event systems. It is shown that there are cases where synthesis with the nonblocking property gives undesired results.
Malik, Robi, Ware, Simon
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Assessing Nurses’ Clinical Competence from Their Own Viewpoint and the Viewpoint of Head Nurses: A Descriptive Study

open access: yesنشریه پرستاری ایران, 2018
Background & Aim: Studies on nurses' clinical competence and its related contextual factors have controversial and sometimes unexpected results. Regarding the role of nurses' clinical competencies in the quality of nursing care, this study aimed to ...
M Adib Hajbaghery, N Eshraghi Arani
doaj  

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