Results 61 to 70 of about 505,633 (274)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Impact of COVID-19 on the Romanian capital market: An assessment of BET index and shares BRD, SNP, TLV, FP & SNP [PDF]

open access: yesRevista de Studii Financiare, 2020
This article studies the response of the Romanian stock market to the COVID-19 pandemic. The research approaches daily data on the number of new confirmed cases, respectively deaths caused by COVID-19 and the returns of the BET index and the share of BRD,
Cătălina Camelia Joldeș
doaj  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Assessing Nurses’ Clinical Competence from Their Own Viewpoint and the Viewpoint of Head Nurses: A Descriptive Study

open access: yesنشریه پرستاری ایران, 2018
Background & Aim: Studies on nurses' clinical competence and its related contextual factors have controversial and sometimes unexpected results. Regarding the role of nurses' clinical competencies in the quality of nursing care, this study aimed to ...
M Adib Hajbaghery, N Eshraghi Arani
doaj  

Impact of OECD Membership on Romania’s Financial Services and Corporate Governance [PDF]

open access: yesRevista de Studii Financiare
OECD membership will have impact for Romania’s economic activity overall. Next significant influence would be the one on the financial services and corporate governance of the companies.
Valentin Ionescu
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Can Big Data Help Predict Financial Market Dynamics?: Evidence from the Korean Stock Market

open access: yesEast Asian Economic Review, 2017
This study quantifies the dynamic interrelationship between the KOSPI index return and search query data derived from the Naver DataLab. The empirical estimation using a bivariate GARCH model reveals that negative contemporaneous correlations between the
Dong-Jin Pyo
doaj   +1 more source

Non-blocking supervisory control for initialised rectangular automata [PDF]

open access: yes, 2004
We consider the problem of supervisory control for a class of rectangular automata and more specifically for compact rectangular automata with uniform rectangular activity, i.e. initialised.
Spathopoulos, Michael P.
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

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