Results 191 to 200 of about 3,869,430 (327)

Two classes of amine/glutamate multi-transmitter neurons innervate Drosophila internal male reproductive organs. [PDF]

Elife
Chaverra M, Toney JP, Dardenne-Ankringa LD, Knee JT, Morris AR, Wadhams JB, Certel SJ, Stowers RS.   +7 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Phenylhydrazone-based endoplasmic reticulum proteostasis regulator compounds with enhanced biological activity. [PDF]

Elife
Kline GM, Boinon L, Guerrero A, Kutseikin S, Cruz G, Williams MP, Paxman RJ, Balch WE, Kelly JW, Mu T, Wiseman RL.   +10 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Regulatory bodies must critically assess their role in the wellness wave of supplement marketing. [PDF]

Lancet Reg Health Am
Marcon AR.
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Branched actin polymerization drives invasive protrusion formation to promote myoblast fusion during mouse skeletal muscle regeneration. [PDF]

Elife
Lu Y, Walji T, Pandey P, Zhou C, Habela CW, Snapper SB, Li R, Chen EH.   +7 more
europepmc   +1 more source

Vitamin supplementation [PDF]

Acta Physiologica, 2017
P B, Persson, A B, Persson
openaire   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Affinity-guided labeling reveals P2X7 nanoscale membrane redistribution during BV2 microglial activation. [PDF]

Elife
Arnould B, Martz A, Belzanne P, Peralta FA, Cevoli F, Hovhannisyan V, Goumon Y, Hosy E, Specht A, Grutter T.   +9 more
europepmc   +1 more source