Results 71 to 80 of about 733,703 (294)

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Efeito da suplementação de zinco a crianças de 1 a 5 anos de idade Effects of zinc supplementation on 1- to 5-year old children

Jornal de Pediatria, 2006
OBJETIVO: Avaliar o impacto da suplementação com zinco sobre os parâmetros nutricionais e bioquímicos entre crianças de 12 a 59 meses de idade. MÉTODOS: Foi realizado um estudo clínico randomizado unicego com 58 crianças entre 12 e 59 meses participantes
Adriana P. R. Silva, Márcia Regina Vitolo, Luis Fabrício Zara, Carlos Frederico S. Castro   +3 more
doaj   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Produção de forragem e rentabilidade da recria de novilhos de corte em área de várzea Production of forage and economic return in Italian ryegrass pasture under grazing with beef cattle in lowland area

Revista Brasileira de Zootecnia, 2005
O experimento foi realizado em 2000 (Ano 1) e 2001 (Ano 2), em várzea sistematizada, com o objetivo de comparar o uso de doses de adubação nitrogenada em cobertura, associadas a níveis de suplementação energética, sobre os teores de proteína bruta ...
Gelson dos Santos Difante, Enio Marchezan, Marta Gomes da Rocha, Tommi Segabinazzi, Silvio Carlos Cazarotto Villa, Simone Michelon   +5 more
doaj   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Avaliação da eficácia da suplementação com melaço na dieta de ratos normais e depletados

Archivos Latinoamericanos de Nutrición, 2000
O melaço, subproduto da industrialização da cana-de-açúcar, tem sido bastante utilizado na alimentação desde a colonização do Brasil. A eficácia da suplementação alimentar com o melaço no estado nutricional e nos níveis de hemoglobina, foi avaliada em ...
M.J. de C. C. Costa, L.H.M. Moraes, F.M. Bion, M.A.A. Rivera, L.S.A. Moura, M.L. Conceição   +5 more
doaj  

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Stress-Axis Regulation by Vitamin D3 in Multiple Sclerosis

Frontiers in Neurology, 2018
IntroductionMultiple sclerosis (MS) has been associated with both a poor vitamin D status and hyperactivity of the hypothalamus–pituitary–adrenal (HPA) axis.
Linda Rolf, Linda Rolf, Jan Damoiseaux, Inge Huitinga, Dorien Kimenai, Jody van den Ouweland, Raymond Hupperts, Raymond Hupperts, Joost Smolders, Joost Smolders, Joost Smolders   +10 more
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Effect of supplementation of low dose intravenous dexmedetomidine on characteristics of spinal anaesthesia with hyperbaric bupivacaine

Indian Journal of Anaesthesia, 2013
Aims: Intravenous (IV) dexmedetomidine with excellent sedative properties has been shown to reduce analgesic requirements during general anaesthesia.
S S Harsoor, D Devika Rani, Bhavana Yalamuru, K Sudheesh, S S Nethra   +4 more
doaj   +1 more source