Results 191 to 200 of about 37,401 (312)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Risk factors influencing construction supply chain management in Saudi Arabia. [PDF]

Sci Rep
Alqahtani FK, Shafaay M, Alagha E, Ahmed O, Alshehri A, Sherif M, Abotaleb IS.   +6 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Supplier evaluation and Selection. A review

Journal of Computer and Information Technology, 2019
MARY WALOWE MWADULO, SAMSON WANJALA MUNIALO   +1 more
openaire   +3 more sources

A simulation-based hybrid causal predictive framework for stockout risk analysis in supply chain. [PDF]

PLoS One
Hafaf E, Alzubi AB, Iyiola K, Aljuhmani HY.   +3 more
europepmc   +1 more source

A Multi-Criteria Decision-Making-based Approach for Green Supplier Evaluation Applied to the Electrical Industry.

reservedThe sustainable supplier selection problem is a strategic problem that plays a significant role in promoting the sustainability of the supply chain.
AFSHARI, MOJTABA
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A sustainability-oriented supply chain supplier selection framework using resilience and HSE performance metrics in the automotive industry. [PDF]

Sci Rep
Maddah S, Padash A, Hajiaghaei-Keshteli M, Bidhendi GRN, Taleizadeh AA, Borhani F.   +5 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Procurement in German office based ambulatory physician practices: system specific challenges and evidence based management strategies. [PDF]

Health Econ Rev
Stope MB.
europepmc   +1 more source