Results 121 to 130 of about 5,758,776 (359)

System Dynamics Simulation to Test Operational Policies in the Milk-Cheese Supply Chain Case study: Piar Municipality, Bolivar State, Venezuela. [PDF]

, 2008
With the purpose of detecting the impact that variations of demand cause in the milk-cheese supply chain, and determining how the operational policies of capacity, inventories or labor force can mitigate this impact, a system dynamics simulation model ...
Fuentes-Pila Estrada, Joaquin, Guaita, Wilfredo, Rodríguez Monroy, Carlos   +2 more
core   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Double Deep Q-Network-Based Solution to a Dynamic, Energy-Efficient Hybrid Flow Shop Scheduling System with the Transport Process

Systems
In this paper, a dynamic energy-efficient hybrid flow shop (TDEHFSP) scheduling model is proposed, considering random arrivals of new jobs and transport by transfer vehicles.
Qinglei Zhang, Huaqiang Si, Jiyun Qin, Jianguo Duan, Ying Zhou, Huaixia Shi, Liang Nie   +6 more
doaj   +1 more source

Benchmarking criteria for evaluating third-party logistics providers in South Africa

Journal of Transport and Supply Chain Management, 2017
Background: In South Africa, deemed the ‘gateway to Africa’, there is limited evidence of the existence of a survey ranking third-party logistics providers (3PLs).
Claudia Karrapan, Mndeni Sishange, Elana Swanepoel, Peter J. Kilbourn   +3 more
doaj   +1 more source

Pengukuran Kinerja Supply Chain Menggunakan Scor Dan Aplikasi Analytic Network Process (Anp) Di PT. Pertiwi Mas Adi Kencana Sidoarjo [PDF]

, 2009
Penelitian ini bertujuan untuk mengidentifikasi indikator kinerja Supply Chain Perusahaan yang memerlukan prioritas untuk dilakukan suatu perbaikan.
Iriani, M. (Mrs)
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The Logistic Principles for Fast Flexible Strategy Design of the Company in Crisis Time [PDF]

The article deals with design of the logistic principles enabling an enterprise to create a strategy flexible in terms of business and marketing and stable and steady in terms of manufacturing. In order to create a strategy model the following principles
Dusan Malindzak, Jaroslav Mervart, Radim Lenort   +2 more
core  

Modelling very large complex systems using distributed simulation: A pilot study in a healthcare setting [PDF]

, 2006
Modern manufacturing supply chains are hugely complex and like all stochastic systems, can benefit from simulation. Unfortunately supply chain systems often result in massively large and complicated models, which even today’s powerful computers cannot ...
Brailsford, S, Katsaliaki, K, Mustafee, N, Taylor, SJE   +3 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source