Results 121 to 130 of about 1,702,773 (334)
Engineering ProceedingsRising carbon emissions are worsening global climatic conditions, posing a grave threat to the environment. Analysing and reducing carbon footprints are vital for combating climate change.
Gangavarapu Chenchu Chythanya Krishna +5 more
doaj +1 more source
Molecular Oncology, EarlyView.This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci +6 more
wiley +1 more source
Sustainable Supply Chains: Introduction
, 2016 As firms become progressively more tightly coupled in global supply chains, rather than being large vertically integrated monoliths, risks and opportunities associated with activities, upstream or downstream, will increasingly impinge upon their own well-being.
Bouchery, Yann +3 more
openaire +3 more sources
Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source
A General Simulation Framework for Supply Chain Modeling: State of the Art and Case Study
, 2010 Nowadays there is a large availability of discrete event simulation software that can be easily used in different domains: from industry to supply chain, from healthcare to business management, from training to complex systems design.
Cimino, Antonio +2 more
core +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Reflecting on theory development in sustainable supply chain management
Cleaner Logistics and Supply Chain, 2022 Sustainable supply chain management (SSCM) emerged as a niche topic around 20 years ago but moved into the mainstream. This paper revisits some of the conceptual developments of the field-building on Seuring and Müller (2008). We draw upon this framework
Stefan Seuring +5 more
doaj
Speeding up the progress curve towards effective supply chain management [PDF]
, 2000 D.R. Towill +2 more
openalex +1 more source
, 2018 The objective of a supply chain strategy is to reduce waste and increase efficiency to attain cost benefits, and to guarantee supply chain flexibility when facing the ever-changing market environment in order to meet customer requirements. Strategy implementation aims to fulfill common goals and attain benefits by integrating upstream and downstream ...
Kuo, Yi-Chun, Jo-Chieh Lin
openaire +1 more source
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source