Results 61 to 70 of about 58,819 (265)

Dynamic Governance of Electric Vehicle Supply Chain Network Resilience Under Disruption Risks

Systems
In the context of multiple overlapping uncertainties, upstream disruptions in electric vehicle supply chain networks are becoming increasingly frequent. Given the dynamic and sudden nature of disruption risks, this paper introduces a stochastic stopping ...
Xuan Wang, Xiaoye Zhou, Meilin Zhu
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Decision analysis considering the resilience level of the food supply chain under the risk of demand disruption

Frontiers in Sustainable Food Systems
In the context of demand disruption, food supply chain resilience not only helps enterprises maintain stability in the face of uncertainty and risk but also enables them to better satisfy customer demand, reduce costs, enhance competitiveness, and ...
Jianyu Liu, Jianyu Liu, Kai Kang, Lin Lu, Lin Lu, Ruihai Dong, Ruihai Dong, Xiaochun Luo, Chaoling Li, Ping Long, Xiangjun Yang, Siyi Mao   +11 more
doaj   +1 more source

Prioritization of petroleum supply chains’ disruption management strategies using combined framework of BSC approach, fuzzy AHP and fuzzy Choquet integral operator

Journal of Business Economics and Management, 2017
Industries in every sector have observed tangible losses from a broad range of disruptions during recent years. Factors such as globalization and outsourcing have made supply chains more sophisticated and this makes disruption management more necessary ...
Fatemeh Ghasemzadeh, Mahsa Pishdar, Jurgita Antuchevičienė   +2 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Disruptions in the food supply chain: A literature review

Heliyon
Disruptions in the food supply chain are events that affect the flow of products and can be caused by extreme weather, natural disasters, conflicts, pandemics, and political situations, among others. These events can significantly impact food products' availability, quality, and cost, creating risks to the well-being of local populations and ...
Juan J. Rojas-Reyes, Leonardo Rivera-Cadavid, Diego L. Peña-Orozco   +2 more
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

COVID-19-related supply chain disruptions: resilience and vulnerability of micro, small and medium enterprises

Cogent Business & Management
The COVID-19 outbreak created a global public health crisis to which governments responded with several measures, including a lockdown on social and economic activities.
Vincent Canwat
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source