Results 81 to 90 of about 58,819 (265)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Fake news on Facebook and their impact on supply chain disruption during COVID-19. [PDF]

Ann Oper Res, 2022
Hossain MA, Chowdhury MMH, Pappas IO, Metri B, Hughes L, Dwivedi YK.   +5 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Supply chain disruption recovery in the evolving crisis-Evidence from the early COVID-19 outbreak in China. [PDF]

Transp Res E Logist Transp Rev, 2023
Fan D, Lin Y, Fu XM, Yeung ACL, Shi X.
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Assessing risk of supply chain disruption due to COVID-19 with fuzzy VIKORSort. [PDF]

Ann Oper Res, 2022
Khan J, Ishizaka A, Mangla SK.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Impact of Supply Chain Disruptions on Economic Growth: Insights From a Major Public Health Crisis

Inquiry: The Journal of Health Care Organization, Provision, and Financing
Supply chain disruptions caused by major public health crises will severely impact the economic growth. The main purpose of this paper is to examine the above proposition, taking the strict lockdown policy and supply chain disruption in Hubei Province at
Hui Jin, Jiamin Xue, Kuen-Lin Lin, Haochuan Yang, Zhenyu Zhu   +4 more
doaj   +1 more source

Generative AI Application, Risk Governance Transformation, and Corporate Supply Chain Disruption Risk Exposure

Systems
Against the backdrop of frequent global shocks and increasingly complex supply chain networks, supply chain disruption risk exposure has become a major challenge affecting firms’ operational stability and sustainable competitive advantage.
Changshuai Li, Hongyu Pan, Min Zhou, Zhengchu He   +3 more
doaj   +1 more source

Role of fake news and misinformation in supply chain disruption: impact of technology competency as moderator. [PDF]

Ann Oper Res, 2022
Chatterjee S, Chaudhuri R, Vrontis D.
europepmc   +1 more source