Results 81 to 90 of about 547,906 (303)
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
A Sustainable Healthcare Supply Chain Model Based on Big Data Analytics, Lean Operations, and Integration [PDF]
Industrial Management JournalObjective: In recent years, big data analytics (BDA) technologies have garnered increasing attention from researchers. However, limited empirical research has explored the benefits of BDA in supply chain integration and lean operations and its influence ...
Fatemeh Khodabakhshi Parizi +2 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Achieving Supply Chain Integration within Construction Industry
Australasian Journal of Construction Economics and Building, 2012 The main driver behind the adoption of supply chain management (SCM) philosophy into the construction industry was the successes within other industry sectors.
Peter McDermotti, Malik Khalfan
doaj +3 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Development of a Supply Chain Integration Process
IEEE Access, 2018 The purpose of this paper was to align integrative tactics and coordination program to develop a supply chain integration process. The taxonomy approach was employed in this paper. An empirical sample comprising 655 responses to the International Manufacturing Strategy Survey was used to test the research question.
Ping-Kuo Chen +3 more
openaire +2 more sources
Environmental scanning, supply chain integration, responsiveness, and operational performance
International Journal of Operations & Production Management, 2019 Purpose It remains unclear how environmental scanning (ES) can generate firm performance through supply chain management (SCM) practices. The purpose of this paper is to investigate the effects of ES on operational performance through supply chain ...
Wantao Yu +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
The role of supply chain agility in the effectiveness of supply integration on new product innovation performance [PDF]
رویکردهای نوین در مدیریت و بازاریابیThe aim of this research is to study and investigate the impact of supply chain integration dimensions on new product innovation performance through supply chain agility in Pegah Pasteurized Dairy Company in the northwest region of Iran.
elahe nouri +3 more
doaj +1 more source