Results 91 to 100 of about 547,906 (303)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
SUPPLY CHAIN MANAGEMENT AND PERFORMANCE: FRAMEWORK FOR STRATEGIC DECISION MAKING [PDF]
Annals of the University of Oradea: Economic Science, 2018 Fast paced technological innovation in the 21st century is continuously transforming the complex world of logistics, a performant strategy in the supply chain (SC) becoming a competitive advantage that all manufacturers strive to improve. Decision making
Florina Simona Burta
doaj
The effects of supply chain integration on supply chain capabilities [PDF]
, 2022 Tedarik zinciri yönetimi, yıllardır çokça çalışılan ve oldukça önemli bir konu olmuştur. Tedarik zinciri entegrasyonu da literatürdeki en popüler konulardan biridir. Birçok araştırma, tedarik zinciri entegrasyonunu, türlerini (tedarikçi entegrasyonu, müşteri entegrasyonu ve içsel entegrasyon) ve aralarındaki ilişkiyi göstermektedir.
openaire
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Applied SciencesDigital–real economy integration constitutes a critical strategic pathway for enhancing supply chain resilience and safeguarding industrial security. This paper takes the listed companies on the Shanghai and Shenzhen A-share markets from 2010 to 2024 as ...
Qianjie Li +3 more
doaj +1 more source
Assessment of the impact of management commitment and supply chain integration on SMEs' innovation performance: Moderation role of government support. [PDF]
Heliyon, 2023 Chen H +4 more
europepmc +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The moderating role of industry clockspeed on the relation between supply chain integration practices and new product flexibility. [PDF]
Heliyon, 2023 Sarfraz M +4 more
europepmc +1 more source
Supply Chain Integration, Learning, and Agility: Effects on Performance
Operations and Supply Chain Management: An International Journal, 2019 This study examines the interrelationships among supply chain integration, learning, agility and organizational performance. Survey data were collected from 257 publiclyowned companies in Pakistan, and the hypothesized framework was tested using a ...
Habibullah Khan, J. Wisner
semanticscholar +1 more source