Results 71 to 80 of about 217,315 (319)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Smart City Mobility Readiness in Thailand: A C.A.S.E. Framework Assessment of Connected, Autonomous, Shared, and Electric Transportation

Smart Cities
Smart city development depends on the readiness of Connected, Autonomous, Shared, and Electric (C.A.S.E.) mobility systems to deliver sustainable, data-driven urban transportation. This paper assesses C.A.S.E.
Sakgasem Ramingwong, Salinee Santiteerakul, Apichat Sopadang, Korrakot Yaibuathet Tippayawong, Poti Chaopaisarn, Tanyanuparb Anantana, Jutamat Jintana   +6 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Energy resources: Trajectories for supply chain management [PDF]

, 2013
Purpose: The aim of this research paper is to explain how principles of supply chain management (SCM) provide important conditions for the production, accessibility and use of energy, from the point of origin to the point of consumption.
Halldorsson, Arni, Halldorsson, Arni,, Svanberg, Martin,, Svanberg, Martin   +3 more
core   +1 more source

Taxonomy of digital signage message execution and media placement considerations [PDF]

The Retail and Marketing Review, 2020
Digital signage is a commercial promising field in marketing. Yet, it is a little researched topic, with an incomplete understanding of the factors to consider when planning digital signage message executions or media placements.
E M Xaba, AT Roux, GAP Drotsky
doaj  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Supply Chain Management - Referenzmodell und Marktstudie [PDF]

, 2022
S.55-60Die Umsetzung von Konzepten des Supply Chain Management (SCM) und damit die stärkere Vernetzung von logistischen Prozessen vieler Unternehmen eines Wertschöpfungsnetzwerkes ist heute aktueller denn je.
Laakmann, F., Nayabi, K., Hellingrath, B., Gehr, F.   +3 more
core  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Dancing the Supply Chain: Toward Transformative Supply Chain Management [PDF]

Journal of Supply Chain Management, 2020
Most of the theories that have dominated supply chain management (SCM) take a reductionist and static view on the supply chain and its management, promoting a global hunt for cheap labor and resources. As a result, supply chains tend to be operated without much concern for their broader contextual environment.
openaire   +2 more sources