Results 51 to 60 of about 131,182 (269)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Benchmarking criteria for evaluating third-party logistics providers in South Africa

Journal of Transport and Supply Chain Management, 2017
Background: In South Africa, deemed the ‘gateway to Africa’, there is limited evidence of the existence of a survey ranking third-party logistics providers (3PLs).
Claudia Karrapan, Mndeni Sishange, Elana Swanepoel, Peter J. Kilbourn   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Speech Emotion Recognition Based on Simultaneously Fusing and Transferring of Multilevel Speech Features

Journal of Electrical and Computer Engineering
To enhance the accuracy of speech emotion recognition using multilevel features, it is essential to simultaneously integrate emotional information and reduce distribution mismatches among multilevel features.
Cheng Zha, Yuzang Tang
doaj   +1 more source

Building digital platform ecosystems: A synthetization of fundamental design topics from a literature review

Digital Business
The purpose of this paper is to contribute to the existing body of research on digital platforms by adopting an ecosystem perspective and considering an established framework. Through our work, we synthesize previous findings related to digital platforms
Thomas Goertler, Marcel Papert, Isabel Fischer, Malou Schmidt   +3 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Understanding Young Consumers’ E-Waste Recycling Behaviour in Bangladesh: A Developing Country Perspective

Recycling
The rising amount of electronic waste (e-waste) presents serious threats to the environment and public health. Addressing this challenge necessitates a focus on improving the e-waste recycling rate, which is facilitated by consumers’ spontaneous ...
Md Hasibul Islam, Md. Tamzidul Islam, Mohammad Rashedul Hoque, Shahnaz Zarin Haque, Bikash Barua, M. M. Obaidul Islam, Md. Faruque Hossain   +6 more
doaj   +1 more source

Kaizen practices and performance improvement in Zambian manufacturing companies

Cogent Engineering, 2023
There is strong evidence that Zambian manufacturing organisations are increasingly implementing Kaizen programs to help them improve productivity and enhance delivery performance.
Chanda Sichinsambwe, Peter Lubosi Simasiku, Shem Sikombe, Harris Nyimbili   +3 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Smart City Mobility Readiness in Thailand: A C.A.S.E. Framework Assessment of Connected, Autonomous, Shared, and Electric Transportation

Smart Cities
Smart city development depends on the readiness of Connected, Autonomous, Shared, and Electric (C.A.S.E.) mobility systems to deliver sustainable, data-driven urban transportation. This paper assesses C.A.S.E.
Sakgasem Ramingwong, Salinee Santiteerakul, Apichat Sopadang, Korrakot Yaibuathet Tippayawong, Poti Chaopaisarn, Tanyanuparb Anantana, Jutamat Jintana   +6 more
doaj   +1 more source