Results 31 to 40 of about 123,299 (269)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Human Factors Influencing the Implementation of Cobots in High Volume Distribution Centres

Logistics, 2021
Order picking is a logistics component of warehouse operations where substantial productivity gains are possible. In this study, we investigate implementation processes of collaborative order picking robots (cobots) and focus on the influence of human ...
Wim Lambrechts, Jessica S. Klaver, Lennart Koudijzer, Janjaap Semeijn   +3 more
doaj   +1 more source

Intelligent Supply Chain Management

Journal of Software Engineering and Applications, 2010
Fuzzy Logic is used to derive the optimal inventory policies in the Supply Chain (SC) numbers. We examine the performance of the optimal inventory policies by cutting the costs and increasing the supply chain management efficiency. The proposed inventory policy uses multi-agent and Fuzzy logic, and provides managerial insights on the impact of the ...
Mohammad Zubair Khan, Omar Al-Mushayt, Jahangir Alam 0002, Jorair Ahmad   +3 more
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Forecast accuracy in demand planning: A fast-moving consumer goods case study

Journal of Transport and Supply Chain Management, 2019
Background: An established South African fast-moving consumer goods (FMCG) manufacturer, Company A, sought to address an underperforming supply chain through an attempt to improve demand planning accuracy.
Lisa M. Basson, Peter J. Kilbourn, Jackie Walters   +2 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Convergence of logistics planning and execution in outsourcing

Journal of Transport and Supply Chain Management, 2015
Background: Logistics service providers (LSPs) are becoming increasingly involved in their clients’ businesses. Beyond just providing vehicles and buildings, LSPs are now becoming involved with knowledge-related work that is connected to the traditional ...
Angela A. D’amato, Sipho Kgoed, Grant Swanepoel, Jacobus Walters, Adri Drotskie, Peter J. Kilbourn   +5 more
doaj   +1 more source

Managing Supply Chain Disruptions

Foundations and Trends® in Technology, Information and Operations Management, 2009
Given the substantive negative financial, marketing, and operations-related consequences of supply chain disruptions, it is not surprising that most organizations are expending significant efforts to develop effective disruption management strategies.
Asoo J. Vakharia, Arda Yenipazarli
openaire   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source