Results 31 to 40 of about 28,574 (252)

Resilience in supply chains - How additive manufacturing enables a resilient supply chain

open access: yes, 2021
Resilience - the ability to deal with crises and recover from their effects as quickly as possible - has been glorified since the COVID-19 pandemic as the new miracle cure against the effects for disruptions that occur in the future. Especially for Germany as an export-oriented location, the resilient design of supply chains is an economic success ...
Kaufmann, Tobias   +6 more
openaire   +3 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Two perspectives on supply chain resilience

open access: yesJournal of Business Logistics, 2021
AbstractMore than a decade ago, other fields started to challenge the equilibrium‐focused meaning of resilience. They suggested that resilience does not just relate to the ability of a system to “bounce back” after an impeding event, but also to the capacity to adapt and transform.
Wieland, Andreas, Durach, Christian F.
openaire   +2 more sources

Artificial Intelligence Usage and Supply Chain Resilience: An Organizational Information Processing Theory Perspective

open access: yesSystems
Frequent disruptions to global supply chains, driven by factors such as trade restrictions and geopolitical conflicts, brought supply chain resilience to the forefront of both academic research and industry practice.
Heng Pan   +4 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

Digital–Real Integration and Supply Chain Resilience: Insights from Stabilization, Complementarity, Extension, and Strengthening Pathways

open access: yesApplied Sciences
Digital–real economy integration constitutes a critical strategic pathway for enhancing supply chain resilience and safeguarding industrial security. This paper takes the listed companies on the Shanghai and Shenzhen A-share markets from 2010 to 2024 as ...
Qianjie Li   +3 more
doaj   +1 more source

Exploring the relationship between supply chain collaboration, risk management strategies, and supplier development on supply chain resilience: The mediating role of trust [PDF]

open access: yesJournal of Project Management
This study investigates the relationships between Supply Chain Collaboration, Risk Management Strategies, Supplier Development, Trust, and Supply Chain Resilience in the Jordanian retail sector.
Adnan Taha   +3 more
doaj   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

open access: yesFEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta   +7 more
wiley   +1 more source

Simulation Analysis of Supply Chain Resilience of Prefabricated Building Projects Based on System Dynamics

open access: yesBuildings, 2023
In light of the intricate dynamics and uncertain risk parameters inherent in the supply chains of prefabricated building projects, bolstering the resilience of these supply chains can substantially mitigate disruption risks and facilitate superior ...
Wei Liu, Zixuan Liu
doaj   +1 more source

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