Results 51 to 60 of about 33,271 (299)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Simulation Analysis of Supply Chain Resilience of Prefabricated Building Projects Based on System Dynamics

Buildings, 2023
In light of the intricate dynamics and uncertain risk parameters inherent in the supply chains of prefabricated building projects, bolstering the resilience of these supply chains can substantially mitigate disruption risks and facilitate superior ...
Wei Liu, Zixuan Liu
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Digital–Real Integration and Supply Chain Resilience: Insights from Stabilization, Complementarity, Extension, and Strengthening Pathways

Applied Sciences
Digital–real economy integration constitutes a critical strategic pathway for enhancing supply chain resilience and safeguarding industrial security. This paper takes the listed companies on the Shanghai and Shenzhen A-share markets from 2010 to 2024 as ...
Qianjie Li, Xinyu Zhao, Zihui Wei, Shi Yin   +3 more
doaj   +1 more source

Creating Supply Chain Resilience Through Scenario Planning: How a Digital Twin Can Be Used To Enhance Supply Chain Resilience Through Scenario Planning

, 2021
This book focusses on the concept of supply chain disruptions and how supply chain resilience can contribute to both preparing for and reacting to the event causing disruption.
Lindquist, Joachim; ARLA Supply Chain, de Haas, Henning; Department of Technology and Business Development, AU   +1 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Artificial Intelligence Usage and Supply Chain Resilience: An Organizational Information Processing Theory Perspective

Systems
Frequent disruptions to global supply chains, driven by factors such as trade restrictions and geopolitical conflicts, brought supply chain resilience to the forefront of both academic research and industry practice.
Heng Pan, Ning Zou, Rouyue Wang, Jingchen Ma, Danping Liu   +4 more
doaj   +1 more source

Exploring the relationship between supply chain collaboration, risk management strategies, and supplier development on supply chain resilience: The mediating role of trust [PDF]

Journal of Project Management
This study investigates the relationships between Supply Chain Collaboration, Risk Management Strategies, Supplier Development, Trust, and Supply Chain Resilience in the Jordanian retail sector.
Adnan Taha, Sarwar Khawaja, Fayyaz Qureshi, Firas Rashed Wahsheh   +3 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source