Results 61 to 70 of about 147,439 (262)

Uncertainty of supply chains: Risk and ambiguity

open access: yesThe World Economy, 2023
AbstractMotivated by the recently experienced systemic shocks (the COVID‐19 pandemic and the full‐fledged Russia's war of aggression against Ukraine)—that have created new forms of uncertainties to our supplies—this paper explores the supply chain robustness under risk aversion and ambiguity aversion.
openaire   +3 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Assessing Supply Chain Cyber Risks

open access: yesCoRR, 2019
Risk assessment is a major challenge for supply chain managers, as it potentially affects business factors such as service costs, supplier competition and customer expectations. The increasing interconnectivity between organisations has put into focus methods for supply chain cyber risk management.
Alberto Redondo   +3 more
openaire   +2 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

The role of supply chain risk mitigation strategies to manage supply chain disruptions

open access: yesJournal of Transport and Supply Chain Management
Background: Supply chain disruptions have always existed, but have become more intense during the last decade or so. Factors in the macro environment have also contributed and none more so than during the coronavirus disease 2019 (COVID-19) pandemic.
Jacobus D. Nel
doaj   +1 more source

Evolutionary Game Dynamics for Financial Risk Decision-Making in Global Supply Chain

open access: yesComplexity, 2018
This paper focuses on the game evolution process and its influencing factors of financial risk cooperation behavior between suppliers and manufacturers in global supply chain system.
Zhi Li, Guanghao Jin, Shen Duan
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

The Mitigation of Risk in Resilient Supply Chains [PDF]

open access: yesInternational Transport Forum Discussion Papers, 2018
This paper examines the sources of supply chain risk and suggests ways in which higher levels of resilience can be achieved. Recent years have seen a significant increase in the risk of supply chain disruption and the need for resilience across the supply/demand network has become imperative.
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Chemical Fuel Supply Chain Integration and Optimization under the Influence of Uncertain Factors

open access: yesChemical Engineering Transactions, 2018
The petrochemical industry belongs to the dangerous chemical industry. The optimization of supply chain can significantly improve the overall profits of enterprises, reducing costs and risks.
Liu Liu
doaj   +1 more source

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