Results 61 to 70 of about 869,912 (305)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Modeling and analysis of supply chain risk system under the influence of partners' collaboration [PDF]

, 2011
Confining the focus to individual enterprise, traditional risk management literature seems to echo inadequately in the context of collaborative supply chain, partially due to its exclusion of correlation of risks across companies.
Yen, BPC, Zeng, B
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Supply chain risks in the South African manufacturing sector

Journal of Transport and Supply Chain Management
Background: Supply chain operations in many organisations are becoming vulnerable to increasing supply chain risks because of unforeseen events that can disrupt the flow of goods and services across the value chain.
Rudzani Tshifhumulo, Gert J. Heyns, Peter J. Kilbourn   +2 more
doaj   +1 more source

Identification and classification of risks in the New Zealand plywood supply chain : thesis presented in fulfilment of the requirements for the degree of Master of Supply Chain Management at Massey University, Palmerston North, New Zealand [PDF]

, 2016
Activities in the supply chain cover a wide-ranging area from upstream to downstream in order to deliver products and services to end customers. Because of the supply chain’s width and scope, the activities in it consume a substantial portion of total
Kusumamurni, Pimpin
core  

A risk assessment model for supply chains

Pressacademia, 2018
Purpose- This research proposes an integrated methodology to assess the risks in supply chains. Methodology- Regarding the importance of risk management in supply chains, an integrated model including Failure Mode Effects Analysis (FMEA), Analytic Hierarchy Process (AHP) and Weighted Product (WP) is proposed.
CANBAKİS, Sena Kubra, KARABAS, Melike, KİLİC, Huseyin Selcuk, KOSEOGLU, Sedef, UNAL, Ezgi   +4 more
openaire   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Dairy Supply Chain Risk Management in Bangladesh: Field studies of Factors and Variables

Jurnal Teknik Industri, 2014
Supply chain risk management (SCRM) has gained wide attention among the academia and the business community in the present competitive business world.
Tasnuba Nasir, Mohammed Quaddus, Mohamamd Shamsuddoha   +2 more
doaj  

Using inventory to mitigate the Ripple effect [PDF]

, 2019
A single disruption at a single location within a supply chain may effect many other locations of a the supply chain through the Ripple effect (Ivanov et al., 2014). In this article we focus on the role of inventory to mitigate the Ripple effect.
Lucker, F.
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source