Results 121 to 130 of about 697,411 (311)

Improving supply chain management in construction: what can be learned from the aerospace industry? [PDF]

open access: yes, 2003
In order to provide for controllable delivery, reliable lead times and efficient customer response, lean manufacturing and platform assembly practices play an important role in supply chains in the aerospace industry.
Voordijk, H., Vrijhoef, R.
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

TRACEABILITY AND CERTIFICATION IN MEAT SUPPLY CHAINS [PDF]

open access: yes
Food safety problems such as the BSE and dioxin crises focused attention on traceability systems and the certification of such systems. This study analyzes the status and perspectives of traceability systems and certification schemes, and reviews their ...
Hogeveen, Henk   +3 more
core   +1 more source

Inventory drivers in a pharmaceutical supply chain [PDF]

open access: yes, 2017
In recent years, inventory reduction has been a key objective of pharmaceutical companies, especially within cost optimization initiatives. Pharmaceutical supply chains are characterized by volatile and unpredictable demands –especially in emergent ...
Masvidal Andreu, Clara
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

GINI’s Odyssey in Greece: Econometric Analysis of Income Inequality, GDP, and Unemployment Through Economic Phases (Pre-Crisis, Crisis, Memoranda, and Post-Memoranda)

open access: yesInternational Journal of Financial Studies
This study explores the relationship between income inequality, economic growth, and unemployment in Greece from 2003 to 2020, encompassing key economic phases: pre-crisis, crisis, memoranda, and post-memoranda. The aim is to analyze how economic growth (
Panagiotis Karountzos   +4 more
doaj   +1 more source

A Conceptual Model for VMI in Reverse Supply Chains [PDF]

open access: yesInternational Journal of Management, Accounting and Economics, 2014
The importance and role of reverse supply chain in gaining competitive advantage has been recognized especially in recent years. However the high costs of implementing and installing these chains works as an impediment for managers.
Mitra Moubed, Yahia Mehrjerdi
doaj  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Research on water footprint in supply chain perspective: A review

open access: yesAgricultural Water Management
The water footprint, as a key indicator for assessing freshwater utilization by nations, regions, and products, clearly demonstrates water resource usage patterns and facilitates the rational utilization and protection of water resources.
QiuXiang Jiang   +4 more
doaj   +1 more source

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