Results 81 to 90 of about 4,713,576 (315)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Leveraging Marketing Analytics to Promote Sustainable Destinations: A Study Across Multiple Continents

World
In an era where environmental consciousness increasingly shapes consumer behaviour, the tourism industry faces the dual challenge of promoting destinations while ensuring ecological sustainability.
Dimitrios P. Reklitis, Nikolaos T. Giannakopoulos, Marina C. Terzi, Damianos P. Sakas, Maria Salamoura, Christina Konstantinidou Konstantopoulou   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Blockchains in operations and supply chains: A model and reference implementation

Computers & industrial engineering, 2019
Blockchain is a promising information technology which can provide several potential applications related to operations and supply chains. By using distributed software architecture and advanced computing, blockchain can solve the problem of immutable ...
P. Helo, Yuqiuge Hao
semanticscholar   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

In This Issue: Short Supply Chains

Journal of Agriculture, Food Systems, and Community Development, 2016
Full text of this issue's editorial: In this issue that completes our sixth volume, we present several papers on short supply chains: food hubs, farm-to-grocers, farmers markets, local grains (in Ethiopia), and, interestingly, two different takes on ...
Duncan Hilchey
doaj   +1 more source

Transparency and sustainability in global commodity supply chains

World Development, 2019
Highlights • The links between transparency and sustainabilityare poorly understood.• We present a typology of information for supply chain governance.• The coverage of existing transparencyinitiatives is limited and biased in scope.• We present ten ways
T. Gardner, M. Benzie, J. Börner, E. Dawkins, Stephen E. Fick, R. Garrett, Javier Godar, A. Grimard, S. Lake, R. K. Larsen, N. Mardas, C. McDermott, P. Meyfroidt, M. Osbeck, M. Persson, T. Sembrés, C. Suavet, B. Strassburg, A. Trevisan, C. West, P. Wolvekamp   +20 more
semanticscholar   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

High-speed rail as a sustainable commuting approach: A ‘pull’ factor in two ‘push’ city clusters in China

Transport Economics and Management
High-speed rail (HSR) has transformed intercity mobility in China, yet its impacts on ordinary residents remain underexplored. This study adopts a grounded theory approach to conduct cross-case analyses of two city clusters, revealing how HSR acts as ...
Adolf K.Y. NG, Xize Wu, Yufeng Lin, Yufei Liu   +3 more
doaj   +1 more source