Results 41 to 50 of about 106,849 (261)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Investment ability: a catalyst for omni-channel supply chain integration

Cogent Business & Management
Digital devices have revolutionized customer shopping behavior, giving rise to omni-channel retailing. Omni-channel retailing seamlessly integrates physical and digital channels, touchpoints, and supply chain operations.
Alicia Neva Weber, Jacoba Orpha Cilliers
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

DIGITAL SUPPLY CHAIN TECHNOLOGY MANAGEMENT USING THE EXAMPLE OF DDEX, DOTBC AND OMI

Вестник Северо-Кавказского федерального университета, 2022
The modern multilevel nature and accessibility of user content makes it difficult to get complete and reliable information about it. This is why companies need to standardize the flow of incoming information in order to simplify its analysis and ...
R. Veynberg, O. Litvishko
doaj  

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Implementation of integrated services of intelligent supply chains by leading Chinese logistics companies.

Управленческие науки
The article examines the restructuring of global supply chains within the framework of the active development of China’s logistics services market. It is established that with the continuous improvement of the country’s digital economy, these services ...
S. Chunxing
doaj   +1 more source

A COMPREHENSIVE MODEL FOR THE POWER TRANSFORMER DIGITAL DIFFERENTIAL PROTECTION FUNCTIONING RESEARCH

Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2016
This article presents a comprehensive model for the two-winding power transformer digital differential protection functioning research. Considered comprehensive model is developed in MatLab-Simulink dynamic simulation environment with the help of ...
Yu. V. Rumiantsev
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Technology trends in the creative and cultural industries sector: a systematic literature review

Journal of Innovation and Entrepreneurship
This article focuses on reviewing technology trends related to the creative and cultural industries (CCIs) and their impact on the development of cultural goods and services.
Luis Ortiz-Ospino, Estiven González-Sarmiento, Jhoselin Roa-Perez   +2 more
doaj   +1 more source