Results 101 to 110 of about 3,698,291 (269)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Real-Time 100 Gbit/s/lambda PAM-4 Fiber Link supporting 4λ Operation with a Common Fiber Amplifier for Future Mobile X-haul and Point to Point Access Networks

, 2022
Jérémy Potet, M. Gay, Laurent Bramerie, Monique Thual, Fabienne Saliou, Gaël Simon, Philippe Chanclou   +6 more
openalex   +1 more source

Evaluation of a pilot outreach program to support point-of-care screening for individuals with diabetes who are experiencing homelessness in Alberta, Canada: results of a mixed methods study. [PDF]

BMC Health Serv Res
Scott S, Grewal EK, Varma M, Campbell DJT.   +3 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Dynamic balance of circles with one support point on pommel horse exercise. [PDF]

Sci Rep
Yamasaki T, Nishiwaki K, Nawa M, Yamawaki K, Nakamura Y, Xin X, Izumi S.   +6 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Development and validation of an advanced data analytics model to support strategic point-of-care testing utilization decisions in the emergency department

Antonio León‐Justel, Marta Jimenez-Barragan, Carmen Navarro-Bustos, Salomon Martin-Perez, Jose M. Garrido-Castilla, Isabel Morales, Fernando Oltra‐Hostalet, M.T. Martín Fernández-Gallardo, Ana Diaz-Luque, Antonia Eugenio-Pizarro, Antonio Luque-Cid, Catalina Sánchez-Mora   +11 more
openalex   +1 more source

Benchmark Repository for Floating-Point Support in KeY

, 2020
Rosa Abbasi, Jonas Schiffl, Eva Darulová, Mattias Ulbrich, Wolfgang Ahrendt   +4 more
openalex   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Social Appraisal Support for Point-of-interest Visiting Decision-making

, 2015
Lien-Fa Lin, Yung-Ming Li
openalex   +1 more source