Results 141 to 150 of about 3,698,291 (269)

Spatial downscaling of multivariate disease risk. [PDF]

Int J Health Geogr
Payares-Garcia D, Osei F, Mateu J, Stein A.   +3 more
europepmc   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Mapping end-of-life care for patients with neurological conditions in German hospices: a point prevalence survey. [PDF]

BMJ Neurol Open
Bublitz SK, Lorenzl S, Klima A, Schmidt S, Schäffer B, Gleich S.   +5 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Nanoparticle-Supported, Point-of-Care Detection of Shiga Toxin-Producing E. coli Infection from Food and Human Specimens [PDF]

Seyedsina Mirjalili, Yeji Choi, Karuppiah Chockalingam, Benjamin Thomas, Xiaohua He, Zhilei Chen, Chao Wang   +6 more
openalex   +1 more source

Application of modified pre-set double-wire intraocular lens suture fixation technique in aphakic eyes: A retrospective study. [PDF]

J Int Med Res
Li Z, Gao W, Wang X, Yang Y.
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Lateral Restraint Brace Forces in Quarter Point and Third Point Plus Support Braced Z-Purlin Supported Roof Systems Subject to Gravity Load

, 1998
Matthew Anthony Danza
openalex   +1 more source

Assessing the Effectiveness of the Human Immunodeficiency Virus Point-of-Care Proficiency Testing Scheme: Analysis of the Data From 2021 to 2022 in South Africa. [PDF]

Health Sci Rep
Blasich NP, Adelekan AM.
europepmc   +1 more source