Results 121 to 130 of about 10,115,754 (295)

Contingent association between the size of the social support network and osteoporosis among Korean elderly women.

PLoS ONE, 2017
ObjectiveTo investigate the association between the number of personal ties (or the size of the social support network) and the incidence of osteoporosis among older women in Korea.MethodsData from the Korean Urban Rural Elderly Study were used.
Seungwon Lee, Da Hea Seo, Kyoung Min Kim, Eun Young Lee, Hyeon Chang Kim, Chang Oh Kim, Yoosik Youm, Yumie Rhee   +7 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Evaluating the fatigue life of notched components based on the stress gradient model with variable support effects

Materials & Design
As the notch location of engineered components suffers from size effect, thereby making it difficult to accurately predict the fatigue life of engineered components.
Zhuo Zhou, Andri Andriyana, Deqing Guan, Jian Chen   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Small and medium-size enterprise support policies in Japan [PDF]

The authors examine how Japan's public and private sectors support small and medium-size enterprises (SMEs). They focus on technical, financial, and marketing assistance.
Motoshige Itoh, Shujiro Urata
core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Same size, same support, same spectator? Selective acetylene hydrogenation on supported Pd nanoparticles

Physical Chemistry Chemical Physics
The selective hydrogenation of acetylene catalyzed by Pd nanoparticles is used in industry to increase the purity of ethylene. To enhance the reaction, the influence of different substrates, i.e. Pt(111) and Mo(211), for use with Pd supported on a-SiO2 thin films, was investigated.
Marian D. Rötzer, Maximilian Krause, Tobias Hinke, Kevin Bertrang, Florian F. Schweinberger, Andrew S. Crampton, Ueli Heiz   +6 more
openaire   +3 more sources

Fast Bayesian Optimization of Machine Learning Hyperparameters on Large Datasets

, 2017
Bayesian optimization has become a successful tool for hyperparameter optimization of machine learning algorithms, such as support vector machines or deep neural networks.
Bartels, Simon, Falkner, Stefan, Hennig, Philipp, Hutter, Frank, Klein, Aaron   +4 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source