Results 41 to 50 of about 427,183 (276)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Bird Species Recognition Using Support Vector Machines

EURASIP Journal on Advances in Signal Processing, 2007
Automatic identification of bird species by their vocalization is studied in this paper. Bird sounds are represented with two different parametric representations: (i) the mel-cepstrum parameters and (ii) a set of low-level signal parameters, both of ...
Seppo Fagerlund
doaj   +1 more source

Mean-Variance optimal portfolio selection integrated with support vector and fuzzy support vector machines [PDF]

Journal of Fuzzy Extension and Applications
This study introduces a novel approach integrating a support vector machine (SVM) with an optimal portfolio construction model. Leveraging the Radial Basis Function (RBF) kernel, the SVM identifies assets with higher growth potential.
Simrandeep Kaur, Arti Singh, Abha Aggarwal   +2 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Modelling Proteolytic Enzymes With Support Vector Machines

Journal of Integrative Bioinformatics, 2011
The strong activity felt in proteomics during the last decade created huge amounts of data, for which the knowledge is limited. Retrieving information from these proteins is the next step. For that, computational techniques are indispensable.
Morgado Lionel, Pereira Carlos, Veríssimo Paula, Dourado António   +3 more
doaj   +1 more source

Communication-Efficient Distributed Learning for High-Dimensional Support Vector Machines

Mathematics, 2022
Distributed learning has received increasing attention in recent years and is a special need for the era of big data. For a support vector machine (SVM), a powerful binary classification tool, we proposed a novel efficient distributed sparse learning ...
Xingcai Zhou, Hao Shen
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Minimal Complexity Support Vector Machines for Pattern Classification

Computers, 2020
Minimal complexity machines (MCMs) minimize the VC (Vapnik-Chervonenkis) dimension to obtain high generalization abilities. However, because the regularization term is not included in the objective function, the solution is not unique.
Shigeo Abe
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source