Results 51 to 60 of about 108,016 (310)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Mean-Variance optimal portfolio selection integrated with support vector and fuzzy support vector machines [PDF]

Journal of Fuzzy Extension and Applications
This study introduces a novel approach integrating a support vector machine (SVM) with an optimal portfolio construction model. Leveraging the Radial Basis Function (RBF) kernel, the SVM identifies assets with higher growth potential.
Simrandeep Kaur, Arti Singh, Abha Aggarwal   +2 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Semismooth support vector machines [PDF]

Mathematical Programming, 2004
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Michael C. Ferris, Todd S. Munson
openaire   +1 more source

Communication-Efficient Distributed Learning for High-Dimensional Support Vector Machines

Mathematics, 2022
Distributed learning has received increasing attention in recent years and is a special need for the era of big data. For a support vector machine (SVM), a powerful binary classification tool, we proposed a novel efficient distributed sparse learning ...
Xingcai Zhou, Hao Shen
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Wasserstein support vector machine: Support vector machines made fair

European Journal of Operational Research
In this paper, a novel model combining Support Vector Machines (SVM) and equity is introduced. Assuming that a group of individuals need to be protected against discrimination, we address the problem of training the classifier by jointly maximizing the classification performance (SVM margin) and equity (closeness between the distribution of the ...
Emilio Carrizosa, Thomas Halskov, Dolores Romero Morales   +2 more
openaire   +2 more sources

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Support Vector Machines for predicting protein structural class

BMC Bioinformatics, 2001
Background We apply a new machine learning method, the so-called Support Vector Machine method, to predict the protein structural class. Support Vector Machine method is performed based on the database derived from SCOP, in which protein domains are ...
Xu Xue-biao, Liu Xiao-Jun, Cai Yu-Dong, Zhou Guo-Ping   +3 more
doaj   +1 more source