Results 71 to 80 of about 869,216 (289)

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Optimized support vector regression for drillingrate of penetration estimation

Open Geosciences, 2015
In the petroleum industry, drilling optimizationinvolves the selection of operating conditions for achievingthe desired depth with the minimum expenditurewhile requirements of personal safety, environment protection,adequate information of penetrated ...
Bodaghi Asadollah, Ansari Hamid Reza, Gholami Mahsa   +2 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Financial time series forecasting using twin support vector regression.

PLoS ONE, 2019
Financial time series forecasting is a crucial measure for improving and making more robust financial decisions throughout the world. Noisy data and non-stationarity information are the two key factors in financial time series prediction.
Deepak Gupta, Mahardhika Pratama, Zhenyuan Ma, Jun Li, Mukesh Prasad   +4 more
doaj   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Parameters Tuning in Support Vector Regression for Reliability Forecasting

Chemical Engineering Transactions, 2013
The recent and promising machine learning technique called support vector machine (SVM) has become a hot research subject in time series forecasting, since proposed from Statistic Learning Theory by Vapnik.
W. Zhao, T. Tao, E. Zio
doaj   +1 more source

Modeling composed nanoparticles of chitosan-N-acetylene-L-cysteine with support vector regression

AIP Advances, 2020
The process of nanoemulsion was improved by optimizing the concentration of chitosan-N-acetylene-L-cysteine and sodium tripolyphosphate and the volume ratio between the two components.
Xueyan Nan, Weidong Shi, Jun Wang, Liang He, Tong Wang, Huilin Yang, Wei Hu, Jun Lin, Pengli Bai   +8 more
doaj   +1 more source

Twin Support Vector Regression for complex millimetric wave propagation environment

Heliyon, 2020
In this article, an effective millimetric wave channel estimation algorithm based on Twin Support Vector Regression (TSVR) is proposed. This algorithm exploits Discrete Wavelet Transform (DWT) in order to denoise samples in learning phase and then ...
Anis Charrada, Abdelaziz Samet
doaj   +1 more source