Results 151 to 160 of about 1,767,596 (309)
, 2010 Work design has long been found to affect employee well-being, but scholars have begun to question whether the established theoretical relations regarding work design continue to hold given the enormous changes in the nature of work during the past two ...
Panatik, Siti Aisyah
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Exploring Multimedia Web Conferencing [PDF]
Internet changed the perspective on meetings and also on decision making processes. Virtualization of meetings has become a common way for collaboration among employees, customers, partners, trainees and trainers, etc.
Florin Gheorghe FILIP +2 more
core +1 more source
The Effect of Power versus Personal Control on Rape Myth Acceptance [PDF]
, 2014 Much of the literature regarding rape myth acceptance has focused on factors that increase these attitudes, and little research has been done on factors that may decrease rape myth acceptance.
Thorne, Jessica
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Due to the nature of the symptoms experienced by dyslexic individuals (e.g. defective visual processing, short term memory deficit and motor control problems) an investigation into support strategies to aid persons suffering from the condition seems ...
Johnson, Mark
core
Identification of human limb stiffness in 5 DoF and estimation via EMG
, 2012 To approach robustness and optimal performance, biological musculo-skeletal systems can adapt their impedance while interacting with their environment. This property has motivated modern robotic designs including variable-impedance actuators and control
Bayer, Justin +4 more
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source